1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo

• Published in: Antimicrobial Agents and Chemotherapy 1994-10, Vol.38 (10), p.2387-2391
• Main Authors: Bischofberger, N, Hitchcock, M J, Chen, M S, Barkhimer, D B, Cundy, K C, Kent, K M, Lacy, S A, Lee, W A, Li, Z H, Mendel, D B
• Format: Article
• Language: English
• Subjects: Animals; Antiviral Agents; Antiviral Agents - metabolism; Antiviral Agents - pharmacology; Antiviral Agents - toxicity; Cells, Cultured; Cidofovir; Cytosine; Cytosine - analogs & derivatives; Cytosine - metabolism; Cytosine - pharmacology; Cytosine - toxicity; Drug Stability; Female; Humans; Male; Mice; Organophosphonates; Organophosphorus Compounds; Organophosphorus Compounds - metabolism; Organophosphorus Compounds - pharmacology; Organophosphorus Compounds - toxicity; Prodrugs; Prodrugs - metabolism; Prodrugs - pharmacology; Prodrugs - toxicity; Rats; Rats, Sprague-Dawley; Research Article
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.38.10.2387

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