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1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo
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| Published in: | Antimicrobial Agents and Chemotherapy 1994-10, Vol.38 (10), p.2387-2391 |
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| Main Authors: | , , , , , , , , , |
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| container_end_page | 2391 |
| container_issue | 10 |
| container_start_page | 2387 |
| container_title | Antimicrobial Agents and Chemotherapy |
| container_volume | 38 |
| creator | Bischofberger, N Hitchcock, M J Chen, M S Barkhimer, D B Cundy, K C Kent, K M Lacy, S A Lee, W A Li, Z H Mendel, D B |
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| doi_str_mv | 10.1128/AAC.38.10.2387 |
| format | article |
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1752 N Street N.W. • Washington DC 20036
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Print ISSN:
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</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.38.10.2387</identifier><identifier>PMID: 7840575</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Animals ; Antiviral Agents ; Antiviral Agents - metabolism ; Antiviral Agents - pharmacology ; Antiviral Agents - toxicity ; Cells, Cultured ; Cidofovir ; Cytosine ; Cytosine - analogs & derivatives ; Cytosine - metabolism ; Cytosine - pharmacology ; Cytosine - toxicity ; Drug Stability ; Female ; Humans ; Male ; Mice ; Organophosphonates ; Organophosphorus Compounds ; Organophosphorus Compounds - metabolism ; Organophosphorus Compounds - pharmacology ; Organophosphorus Compounds - toxicity ; Prodrugs ; Prodrugs - metabolism ; Prodrugs - pharmacology ; Prodrugs - toxicity ; Rats ; Rats, Sprague-Dawley ; Research Article</subject><ispartof>Antimicrobial Agents and Chemotherapy, 1994-10, Vol.38 (10), p.2387-2391</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a492t-79813c2de426ebd673bc0d5dafad2bf8f6d565a5aaa3991c5ac3f5c77d8e41c53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.asm.org/doi/pdf/10.1128/AAC.38.10.2387$$EPDF$$P50$$Gasm2$$H</linktopdf><linktohtml>$$Uhttps://journals.asm.org/doi/full/10.1128/AAC.38.10.2387$$EHTML$$P50$$Gasm2$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,3188,3189,27924,27925,52751,52752,52753,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7840575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bischofberger, N</creatorcontrib><creatorcontrib>Hitchcock, M J</creatorcontrib><creatorcontrib>Chen, M S</creatorcontrib><creatorcontrib>Barkhimer, D B</creatorcontrib><creatorcontrib>Cundy, K C</creatorcontrib><creatorcontrib>Kent, K M</creatorcontrib><creatorcontrib>Lacy, S A</creatorcontrib><creatorcontrib>Lee, W A</creatorcontrib><creatorcontrib>Li, Z H</creatorcontrib><creatorcontrib>Mendel, D B</creatorcontrib><title>1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><description>Classifications
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</description><subject>Animals</subject><subject>Antiviral Agents</subject><subject>Antiviral Agents - metabolism</subject><subject>Antiviral Agents - pharmacology</subject><subject>Antiviral Agents - toxicity</subject><subject>Cells, Cultured</subject><subject>Cidofovir</subject><subject>Cytosine</subject><subject>Cytosine - analogs & derivatives</subject><subject>Cytosine - metabolism</subject><subject>Cytosine - pharmacology</subject><subject>Cytosine - toxicity</subject><subject>Drug Stability</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>Organophosphonates</subject><subject>Organophosphorus Compounds</subject><subject>Organophosphorus Compounds - metabolism</subject><subject>Organophosphorus Compounds - pharmacology</subject><subject>Organophosphorus Compounds - toxicity</subject><subject>Prodrugs</subject><subject>Prodrugs - metabolism</subject><subject>Prodrugs - pharmacology</subject><subject>Prodrugs - toxicity</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Research Article</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNp1kcuO0zAUhi0EGsrAlh2Sxaoj6mI7ceIsZlFV3KSRWAArhKxT22k8SuLISTrN0_FqOGoZlQULX87l_46tH6HXjK4Z4_L9ZrNdJ3IdQ57I_AlaMFpIkokie4oWlGYZSSVNn6MXfX9PYywKeoWucplSkYsF-s3Iz-Xy2w3hpJpM8Mcp3vzRE7ZKV5wY54_QVb6PK7gWWiLIVN80dqim-hfW0-B719oVhha7dgigbV2PNQTcBW_CuMelD3jmM7JMLkacme1Uz6yYi_1dJP8l4gc3VNg1MX2wBg-VDdDZcXA6zjH2GHd8cAf_Ej0roe7tq_N5jX58_PB9-5ncff30Zbu5I5AWfCB5IVmiubEpz-zOZHmy09QIAyUYvitlmRmRCRAAkBQF0wJ0Ugqd50baNIbJNbo9cbtx11ij7fzZWnXBNRAm5cGpfyutq9TeHxSXaZ4WUb8-6XXwfR9s-ShlVM1GqmikSuQczkZGwbuTAPqGq3s_hjb-7__dby6f9wg_-xzrb0_1yu2rBxesilgFoC8hfwBw6Lbp</recordid><startdate>19941001</startdate><enddate>19941001</enddate><creator>Bischofberger, N</creator><creator>Hitchcock, M J</creator><creator>Chen, M S</creator><creator>Barkhimer, D B</creator><creator>Cundy, K C</creator><creator>Kent, K M</creator><creator>Lacy, S A</creator><creator>Lee, W A</creator><creator>Li, Z H</creator><creator>Mendel, D B</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>19941001</creationdate><title>1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo</title><author>Bischofberger, N ; 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Print ISSN:
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</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>7840575</pmid><doi>10.1128/AAC.38.10.2387</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial Agents and Chemotherapy, 1994-10, Vol.38 (10), p.2387-2391 |
| issn | 0066-4804 1098-6596 |
| language | eng |
| recordid | cdi_highwire_asm_aac_38_10_2387 |
| source | American Society for Microbiology; PubMed (Medline) |
| subjects | Animals Antiviral Agents Antiviral Agents - metabolism Antiviral Agents - pharmacology Antiviral Agents - toxicity Cells, Cultured Cidofovir Cytosine Cytosine - analogs & derivatives Cytosine - metabolism Cytosine - pharmacology Cytosine - toxicity Drug Stability Female Humans Male Mice Organophosphonates Organophosphorus Compounds Organophosphorus Compounds - metabolism Organophosphorus Compounds - pharmacology Organophosphorus Compounds - toxicity Prodrugs Prodrugs - metabolism Prodrugs - pharmacology Prodrugs - toxicity Rats Rats, Sprague-Dawley Research Article |
| title | 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo |
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