Mutational Replacement of Leu-293 in the Class C Enterobacter cloacae P99 β-Lactamase Confers Increased MIC of Cefepime

• Published in: Antimicrobial Agents and Chemotherapy 2002-06, Vol.46 (6), p.1966-1970
• Main Authors: VAKULENKO, Sergei B, GOLEMI, Dasantila, GERYK, Bruce, SUVOROV, Maxim, KNOX, James R, MOBASHERY, Shahriar, LERNER, Stephen A
• Format: Article
• Language: English
• Subjects: Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacteriology; beta-Lactamases; beta-Lactamases - genetics; beta-Lactamases - metabolism; Biological and medical sciences; Cefepime; Cephalosporin Resistance; Cephalosporins; Cephalosporins - pharmacology; Cloning, Molecular; Enterobacter cloacae; Enterobacter cloacae - drug effects; Enterobacter cloacae - enzymology; Enterobacter cloacae - genetics; Fundamental and applied biological sciences. Psychology; Kinetics; Leucine; Leucine - genetics; Mechanisms of Resistance; Medical sciences; Metabolism. Enzymes; Microbial Sensitivity Tests; Microbiology; Models, Molecular; Molecular Conformation; Mutagenesis, Site-Directed; Mutation - genetics; Pharmacology. Drug treatments; Plasmids - genetics
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.46.6.1966-1970.2002

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