Pharmacodynamics of a New Cephalosporin, PPI-0903 (TAK-599), Active against Methicillin-Resistant Staphylococcus aureus in Murine Thigh and Lung Infection Models: Identification of an In Vivo Pharmacokinetic-Pharmacodynamic Target

• Published in: Antimicrobial Agents and Chemotherapy 2006-04, Vol.50 (4), p.1376-1383
• Main Authors: ANDES, D, CRAIG, W. A
• Format: Article
• Language: English
• Subjects: Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Butyrates; Butyrates - pharmacokinetics; Butyrates - pharmacology; Butyrates - therapeutic use; Escherichia coli; Experimental Therapeutics; Female; Medical sciences; Methicillin Resistance; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Oxazoles; Oxazoles - pharmacokinetics; Oxazoles - pharmacology; Oxazoles - therapeutic use; Pharmacology. Drug treatments; Pneumonia, Bacterial; Pneumonia, Bacterial - drug therapy; Staphylococcal Infections; Staphylococcal Infections - drug therapy; Staphylococcus aureus; Staphylococcus aureus - drug effects; Streptococcus pneumoniae; Streptococcus pneumoniae - drug effects; Thigh; Thigh - microbiology
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.50.4.1376-1383.2006

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