Accumulation and Intracellular Distribution of Antitrypanosomal Diamidine Compounds DB75 and DB820 in African Trypanosomes

• Published in: Antimicrobial Agents and Chemotherapy 2006-06, Vol.50 (6), p.2185-2191
• Main Authors: MATHIS, Amanda M, HOLMAN, Jacqueline L, SHIRK, Lisa M, ISMAIL, Mohamed A, BOYKIN, David W, TIDWELL, Richard R, HALL, James Edwin
• Format: Article
• Language: English
• Subjects: Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Benzamidines; Benzamidines - blood; Benzamidines - pharmacokinetics; Benzamidines - pharmacology; Biological and medical sciences; Cell Nucleus - metabolism; Cytoplasm - metabolism; Dose-Response Relationship, Drug; Fluorescence; Furans; Furans - blood; Furans - pharmacokinetics; Furans - pharmacology; In Vitro Techniques; Kinetics; Male; Mechanisms of Action: Physiological Effects; Medical sciences; Mice; Molecular Structure; Organelles - metabolism; Pentamidine; Pentamidine - analogs & derivatives; Pentamidine - pharmacokinetics; Pentamidine - pharmacology; Pharmacology. Drug treatments; Tissue Distribution; Trypanocidal Agents; Trypanocidal Agents - blood; Trypanocidal Agents - pharmacokinetics; Trypanocidal Agents - pharmacology; Trypanosoma brucei gambiense; Trypanosoma brucei gambiense - cytology; Trypanosoma brucei gambiense - drug effects; Trypanosoma brucei gambiense - metabolism
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.00192-06

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