Resistance Analysis and Characterization of a Thiazole Analogue, BP008, as a Potent Hepatitis C Virus NS5A Inhibitor

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Published in:Antimicrobial Agents and Chemotherapy 2012-01, Vol.56 (1), p.44-53
Main Authors: LIN, Hui-Mei, WANG, Jing-Chyi, CHERN, Jyh-Haur, YEH, Teng-Kuang, YUEH, Andrew, HU, Han-Shu, WU, Pei-Shan, YANG, Chi-Chen, WU, Chung-Pu, PU, Szu-Yuan, HSU, Tsu-An, JIAANG, Weir-Torn, CHAO, Yu-Sheng
Format: Article
Language:English
Subjects:
Amino Acid Substitution
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral Agents
Antiviral Agents - pharmacology
Biological and medical sciences
Cell Line, Tumor
Cell Survival - drug effects
Drug Resistance, Viral
Drug Resistance, Viral - drug effects
Drug Synergism
Drug Therapy, Combination
Genes, Reporter
Hepacivirus
Hepacivirus - drug effects
Hepacivirus - genetics
Hepacivirus - metabolism
Hepatitis C, Chronic
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - virology
Hepatocytes - drug effects
High-Throughput Screening Assays
Human viral diseases
Humans
Infectious diseases
Interferon-alpha - pharmacology
Male
Medical sciences
Pharmacology. Drug treatments
Rats
Replicon
Thiazoles
Thiazoles - pharmacology
Viral diseases
Viral hepatitis
Viral Nonstructural Proteins
Viral Nonstructural Proteins - antagonists & inhibitors
Viral Nonstructural Proteins - genetics
Viral Nonstructural Proteins - metabolism
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00599-11