Azole Resistance by Loss of Function of the Sterol Δ5,6-Desaturase Gene (ERG3) in Candida albicans Does Not Necessarily Decrease Virulence

• Published in: Antimicrobial Agents and Chemotherapy 2012-04, Vol.56 (4), p.1960-1968
• Main Authors: VALE-SILVA, L. A, COSTE, A. T, ISCHER, F, PARKER, J. E, KELLY, S. L, PINTO, E, SANGLARD, D
• Format: Article
• Language: English
• Subjects: Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal Agents; Antifungal Agents - pharmacology; Azoles; Azoles - pharmacology; Biofilms; Biological and medical sciences; Blotting, Northern; Blotting, Southern; Candida albicans; Candida albicans - enzymology; Candida albicans - genetics; Candida albicans - pathogenicity; Candidiasis - drug therapy; Candidiasis - microbiology; DNA, Fungal - genetics; Drug Resistance, Fungal; Drug Resistance, Fungal - genetics; Female; Fluconazole - pharmacology; Fluconazole - therapeutic use; Fluorescent Dyes; Gas Chromatography-Mass Spectrometry; Kidney - microbiology; Kidney - pathology; Mechanisms of Resistance; Medical sciences; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidoreductases; Oxidoreductases - genetics; Oxidoreductases - metabolism; Pharmacology. Drug treatments; Rhodamines; Virulence
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.05720-11

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