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MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants
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| Published in: | Antimicrobial Agents and Chemotherapy 2012-08, Vol.56 (8), p.4161-4167 |
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| container_end_page | 4167 |
| container_issue | 8 |
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| container_title | Antimicrobial Agents and Chemotherapy |
| container_volume | 56 |
| creator | SUMMA, Vincenzo LUDMERER, Steven W GATES, Adam T GRAHAM, Donald J HARPER, Steven HAZUDA, Daria J MCHALE, Carolyn MONTEAGUDO, Edith PUCCI, Vincenzo ROWLEY, Michael RUDD, Michael T SORIANO, Aileen MCCAULEY, John A STAHLHUT, Mark W VACCA, Joseph P OLSEN, David B LIVERTON, Nigel J CARROLL, Steven S FANDOZZI, Christine BURLEIN, Christine CLAUDIO, Giuliano COLEMAN, Paul J DIMUZIO, Jillian M FERRARA, Marco DI FILIPPO, Marcello |
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| doi_str_mv | 10.1128/AAC.00324-12 |
| format | article |
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</description><identifier>ISSN: 0066-4804</identifier><identifier>ISSN: 1098-6596</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.00324-12</identifier><identifier>PMID: 22615282</identifier><identifier>CODEN: AACHAX</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Amides ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral Agents ; Antiviral Agents - pharmacology ; Biological and medical sciences ; Carbamates ; Cyclopropanes ; Dogs ; Drug Resistance, Viral ; Genotype ; Hepacivirus ; Hepacivirus - drug effects ; Hepacivirus - enzymology ; Hepacivirus - genetics ; Hepatitis C, Chronic - drug therapy ; Hepatitis C, Chronic - virology ; Liver - drug effects ; Medical sciences ; Pan troglodytes ; Pharmacology. Drug treatments ; Protease Inhibitors ; Protease Inhibitors - pharmacology ; Quinoxalines ; Quinoxalines - metabolism ; Quinoxalines - pharmacokinetics ; Quinoxalines - pharmacology ; Rats ; Sulfonamides ; Viral Load - drug effects ; Viral Nonstructural Proteins ; Viral Nonstructural Proteins - antagonists & inhibitors</subject><ispartof>Antimicrobial Agents and Chemotherapy, 2012-08, Vol.56 (8), p.4161-4167</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012, American Society for Microbiology. All Rights Reserved.</rights><rights>Copyright © 2012, American Society for Microbiology. All Rights Reserved. 2012 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a474t-a817ad881e4217203564fad090eef5fae58e3477932de7c7311c953cd653910c3</citedby><cites>FETCH-LOGICAL-a474t-a817ad881e4217203564fad090eef5fae58e3477932de7c7311c953cd653910c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.asm.org/doi/pdf/10.1128/AAC.00324-12$$EPDF$$P50$$Gasm2$$H</linktopdf><linktohtml>$$Uhttps://journals.asm.org/doi/full/10.1128/AAC.00324-12$$EHTML$$P50$$Gasm2$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,3186,3187,27923,27924,52750,52751,52752,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26180126$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22615282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SUMMA, Vincenzo</creatorcontrib><creatorcontrib>LUDMERER, Steven W</creatorcontrib><creatorcontrib>GATES, Adam T</creatorcontrib><creatorcontrib>GRAHAM, Donald J</creatorcontrib><creatorcontrib>HARPER, Steven</creatorcontrib><creatorcontrib>HAZUDA, Daria J</creatorcontrib><creatorcontrib>MCHALE, Carolyn</creatorcontrib><creatorcontrib>MONTEAGUDO, Edith</creatorcontrib><creatorcontrib>PUCCI, Vincenzo</creatorcontrib><creatorcontrib>ROWLEY, Michael</creatorcontrib><creatorcontrib>RUDD, Michael T</creatorcontrib><creatorcontrib>SORIANO, Aileen</creatorcontrib><creatorcontrib>MCCAULEY, John A</creatorcontrib><creatorcontrib>STAHLHUT, Mark W</creatorcontrib><creatorcontrib>VACCA, Joseph P</creatorcontrib><creatorcontrib>OLSEN, David B</creatorcontrib><creatorcontrib>LIVERTON, Nigel J</creatorcontrib><creatorcontrib>CARROLL, Steven S</creatorcontrib><creatorcontrib>FANDOZZI, Christine</creatorcontrib><creatorcontrib>BURLEIN, Christine</creatorcontrib><creatorcontrib>CLAUDIO, Giuliano</creatorcontrib><creatorcontrib>COLEMAN, Paul J</creatorcontrib><creatorcontrib>DIMUZIO, Jillian M</creatorcontrib><creatorcontrib>FERRARA, Marco</creatorcontrib><creatorcontrib>DI FILIPPO, Marcello</creatorcontrib><title>MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Classifications
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</description><subject>Amides</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral Agents</subject><subject>Antiviral Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carbamates</subject><subject>Cyclopropanes</subject><subject>Dogs</subject><subject>Drug Resistance, Viral</subject><subject>Genotype</subject><subject>Hepacivirus</subject><subject>Hepacivirus - drug effects</subject><subject>Hepacivirus - enzymology</subject><subject>Hepacivirus - genetics</subject><subject>Hepatitis C, Chronic - drug therapy</subject><subject>Hepatitis C, Chronic - virology</subject><subject>Liver - drug effects</subject><subject>Medical sciences</subject><subject>Pan troglodytes</subject><subject>Pharmacology. 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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>22615282</pmid><doi>10.1128/AAC.00324-12</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial Agents and Chemotherapy, 2012-08, Vol.56 (8), p.4161-4167 |
| issn | 0066-4804 1098-6596 1098-6596 |
| language | eng |
| recordid | cdi_highwire_asm_aac_56_8_4161 |
| source | American Society for Microbiology; PubMed Central |
| subjects | Amides Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Antiviral Agents - pharmacology Biological and medical sciences Carbamates Cyclopropanes Dogs Drug Resistance, Viral Genotype Hepacivirus Hepacivirus - drug effects Hepacivirus - enzymology Hepacivirus - genetics Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - virology Liver - drug effects Medical sciences Pan troglodytes Pharmacology. Drug treatments Protease Inhibitors Protease Inhibitors - pharmacology Quinoxalines Quinoxalines - metabolism Quinoxalines - pharmacokinetics Quinoxalines - pharmacology Rats Sulfonamides Viral Load - drug effects Viral Nonstructural Proteins Viral Nonstructural Proteins - antagonists & inhibitors |
| title | MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants |
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