A Class of Tricyclic Compounds Blocking Malaria Parasite Oocyst Development and Transmission

• Published in: Antimicrobial Agents and Chemotherapy 2013-01, Vol.57 (1), p.425-435
• Main Authors: EASTMAN, Richard T, PATTARADILOKRAT, Sittiporn, RUILI HUANG, WILLIAMSON, Kim C, LAMBERT, Lynn E, LONG, Carole, AUSTIN, Christopher P, YIMIN WU, SU, Xin-Zhuan, RAJ, Dipak K, DIXIT, Saurabh, BINGBING DENG, MIURA, Kazutoyo, JING YUAN, TANAKA, Takeshi Q, JOHNSON, Ronald L, HONGYING JIANG
• Format: Article
• Language: English
• Subjects: Animals; Anti-Allergic Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimalarials; Antimalarials - pharmacology; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; Biological and medical sciences; Biological Transport - drug effects; Drug Repositioning; Experimental Therapeutics; General aspects; High-Throughput Screening Assays; Human protozoal diseases; Humans; Infectious diseases; Ketotifen; Ketotifen - analogs & derivatives; Ketotifen - pharmacology; Macaca mulatta; Malaria; Malaria - metabolism; Malaria - parasitology; Malaria - prevention & control; Malaria - transmission; Malaria, Falciparum; Malaria, Falciparum - metabolism; Malaria, Falciparum - parasitology; Malaria, Falciparum - prevention & control; Malaria, Falciparum - transmission; Medical sciences; Mice; Oocysts; Oocysts - drug effects; Oocysts - growth & development; Parasitic diseases; Pharmacology. Drug treatments; Plasmodium cynomolgi - drug effects; Plasmodium cynomolgi - growth & development; Plasmodium falciparum; Plasmodium falciparum - drug effects; Plasmodium falciparum - growth & development; Plasmodium yoelii; Plasmodium yoelii - drug effects; Plasmodium yoelii - growth & development; Protozoal diseases; Protozoan Proteins - genetics; Protozoan Proteins - metabolism; Small Molecule Libraries - chemistry; Small Molecule Libraries - pharmacology
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.00920-12

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