A Mixture of Functionally Oligoclonal Humanized Monoclonal Antibodies That Neutralize Clostridium difficile TcdA and TcdB with High Levels of In Vitro Potency Shows In Vivo Protection in a Hamster Infection Model

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Published in:Clinical and Vaccine Immunology 2013-03, Vol.20 (3), p.377-390
Main Authors: Davies, Nicola L, Compson, Joanne E, Mackenzie, Brendon, O'Dowd, Victoria L, Oxbrow, Amanda K F, Heads, James T, Turner, Alison, Sarkar, Kaushik, Dugdale, Sarah L, Jairaj, Mark, Christodoulou, Louis, Knight, David E O, Cross, Amanda S, Hervé, Karine J M, Tyson, Kerry L, Hailu, Hanna, Doyle, Carl B, Ellis, Mark, Kriek, Marco, Cox, Matthew, Page, Matthew J T, Moore, Adrian R, Lightwood, Daniel J, Humphreys, David P
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - immunology
Antibodies, Monoclonal - isolation & purification
Antibodies, Monoclonal - therapeutic use
Antibodies, Neutralizing - immunology
Antibodies, Neutralizing - isolation & purification
Antibodies, Neutralizing - therapeutic use
Bacterial Proteins - antagonists & inhibitors
Bacterial Proteins - immunology
Bacterial Toxins - antagonists & inhibitors
Bacterial Toxins - immunology
Clinical Immunology
Clostridium difficile
Clostridium Infections - therapy
Cricetinae
Disease Models, Animal
Enterotoxins - antagonists & inhibitors
Enterotoxins - immunology
Immunoglobulin G - immunology
Immunoglobulin G - isolation & purification
Immunoglobulin G - therapeutic use
Immunologic Factors - immunology
Immunologic Factors - isolation & purification
Immunologic Factors - therapeutic use
Treatment Outcome
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Summary:OA  Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue CVI About CVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy CVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 1556-6811 Online ISSN: 1556-679X Copyright © 2014 by the American Society for Microbiology.   For an alternate route to CVI .asm.org, visit: CVI       
ISSN:1556-6811
1556-679X
1556-679X
DOI:10.1128/CVI.00625-12