α1,3 Glucans Are Dispensable in Aspergillus fumigatus

A triple α1,3 glucan synthase mutant of Aspergillus fumigatus obtained by successive deletions of the three α1,3 glucan synthase genes (AGS1, AGS2, and AGS3) has a cell wall devoid of α1,3 glucans. The lack of α1,3 glucans affects neither conidial germination nor mycelial vegetative growth and is co...

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Bibliographic Details
Published in:Eukaryotic Cell 2012, Vol.11 (1), p.26-29
Main Authors: Henry, Christine, Latgé, Jean-Paul, Beauvais, Anne
Format: Article
Language:English
Subjects:
Aspergillus fumigatus
Aspergillus fumigatus - enzymology
Aspergillus fumigatus - genetics
Aspergillus fumigatus - physiology
Cell Wall
Cell Wall - metabolism
cell walls
Chitin
Chitin - metabolism
conidia
Fungal Proteins
Fungal Proteins - genetics
Gene Knockout Techniques
genes
Genetic Engineering
germination
Glucans
Glucans - metabolism
Glucosyltransferases
Glucosyltransferases - genetics
Life Sciences
Microbial Viability
Microbiology and Parasitology
mutants
Mycelium
Mycelium - enzymology
Mycelium - genetics
Mycelium - physiology
Mycology
Phenotype
Spores, Fungal
Spores, Fungal - enzymology
Spores, Fungal - genetics
Spores, Fungal - physiology
vegetative growth
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Summary:A triple α1,3 glucan synthase mutant of Aspergillus fumigatus obtained by successive deletions of the three α1,3 glucan synthase genes (AGS1, AGS2, and AGS3) has a cell wall devoid of α1,3 glucans. The lack of α1,3 glucans affects neither conidial germination nor mycelial vegetative growth and is compensated by an increase in β1,3 glucan and/or chitin content.
ISSN:1535-9778
1535-9786
DOI:10.1128/ec.05270-11