Safety, immunogenicity, and transmissibility in humans of CVD 1203, a live oral Shigella flexneri 2a vaccine candidate attenuated by deletions in aroA and virG

• Published in: Infection and Immunity 1996-11, Vol.64 (11), p.4542-4548
• Main Authors: KOTLOFF, K. L, NORIEGA, F, LOSONSKY, G. A, SZTEIN, M. B, WASSERMAN, S. S, NATARO, J. P, LEVINE, M. M
• Format: Article
• Language: English
• Subjects: 3-Phosphoshikimate 1-Carboxyvinyltransferase; Adult; Alkyl and Aryl Transferases; Antibodies, Bacterial - biosynthesis; Antibody-Producing Cells - immunology; Antigens, Bacterial - immunology; Bacterial Proteins; Bacterial Vaccines - administration & dosage; Bacterial Vaccines - adverse effects; Bacterial Vaccines - immunology; Bacteriology; Biological and medical sciences; DNA-Binding Proteins - genetics; Double-Blind Method; Feces - chemistry; Feces - microbiology; Fundamental and applied biological sciences. Psychology; Gene Deletion; Humans; Immunization Schedule; Immunoglobulin A - analysis; Immunoglobulin A - biosynthesis; Lipopolysaccharides - immunology; Microbiology; Shigella flexneri; Shigella flexneri - genetics; Shigella flexneri - immunology; Shigella flexneri - isolation & purification; Transcription Factors - genetics; Transferases - genetics; Tumor Necrosis Factor-alpha - analysis; Vaccination; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - adverse effects; Vaccines, Attenuated - immunology
• ISSN: 0019-9567; 1098-5522
• DOI: 10.1128/IAI.64.11.4542-4548.1996

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