The baboon as a nonhuman primate model for assessing the effects of maternal immunization with Haemophilus influenzae type b polysaccharide vaccines

• Published in: Infection and Immunity 1997-08, Vol.65 (8), p.3267-3270
• Main Authors: Shearer, M.H. (Oklahoma Health Science Center, Oklahoma City, OK.), Lucas, A.H, Anderson, P.W, Carey, K.D, Jenson, H.B, Chanh, T.C, Stanley, J.R, Kennedy, R.C
• Format: Article
• Language: English
• Subjects: Animals; Antibodies, Bacterial - blood; Bacterial Capsules; Bacteriology; Biological and medical sciences; Female; Fundamental and applied biological sciences. Psychology; HAEMOPHILUS; Haemophilus influenzae; Haemophilus Vaccines - immunology; IMMUNISATION; Immunization; INMUNIZACION; Microbiology; Papio; Polysaccharides, Bacterial - immunology; Pregnancy; Pregnancy, Animal - immunology; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Vaccines, Conjugate - immunology
• ISSN: 0019-9567; 1098-5522
• DOI: 10.1128/IAI.65.8.3267-3270.1997

These studies were performed to assess the utility of the baboon as a nonhuman primate model to evaluate vaccines for use in humans. Specifically, we examined the antibody response of baboons immunized during the third trimester of pregnancy with Haemophilus influenzae type b (Hib) polyribosylribitol phosphate (PRP) conjugate and unconjugated polysaccharide vaccines. Some of the vaccinated mothers failed to respond to a single immunization with unconjugated Hib PRP. Specific Hib PRP immunoglobulin G (IgG) but not IgM antibodies cross the baboon placenta and are detected in the offspring. Higher-titer baboon anti-Hib PRP did not express two previously defined cross-reactive human anti-Hib PRP idiotypes and was biased towards lambda light-chain expression. Spectrotype analysis indicated that baboon anti-Hib PRP was restricted in heterogeneity and oligoclonal