Shiga Toxin Binding to Isolated Porcine Tissues and Peripheral Blood Leukocytes

Shiga toxin (Stx) binding sites in porcine tissues and leukocytes were identified by the use of Stx overlay and anti-CD77/Gb3 immunoassays. Stx1 and Stx2 bound to similar tissue locations and leukocytes, although some differences were noted. Previously unreported Stx binding sites were identified in...

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Bibliographic Details
Published in:Infection and Immunity 2004-11, Vol.72 (11), p.6680-6684
Main Authors: Winter, Kellie R.K, Stoffregen, William C, Dean-Nystrom, Evelyn A
Format: Article
Language:English
Subjects:
alveolar macrophages
Animals
Binding Sites
Biological and medical sciences
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Escherichia coli
Fundamental and applied biological sciences. Psychology
Hepatocytes - metabolism
Immunoassay
intestinal lymphoid aggregates
intestines
Kidney Tubules - metabolism
kidneys
leukocytes
Leukocytes, Mononuclear - metabolism
liver
lymphoid tissue
macrophages
Macrophages, Alveolar - metabolism
Microbiology
Organ Specificity
renal tubules
Shiga toxin
Shiga Toxin 1 - metabolism
Shiga Toxin 2 - metabolism
Shiga-like toxin 1
Shiga-like toxin 2
sinusoidal liver cells
Swine
Trihexosylceramides - immunology
Trihexosylceramides - metabolism
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Summary:Shiga toxin (Stx) binding sites in porcine tissues and leukocytes were identified by the use of Stx overlay and anti-CD77/Gb3 immunoassays. Stx1 and Stx2 bound to similar tissue locations and leukocytes, although some differences were noted. Previously unreported Stx binding sites were identified in kidney tubules, intestinal lymphoid aggregates, sinusoidal liver cells, alveolar macrophages, and peripheral blood leukocytes.
ISSN:1098-5522
0019-9567
1098-5522
DOI:10.1128/IAI.72.11.6680-6684.2004