Gamma Interferon Suppresses Erythropoiesis via Interleukin-15

Impaired erythropoiesis causes anemia during genetic disorders, chronic disease, and infection. In studies of the underlying mechanisms researchers have increasingly focused on gamma interferon (IFN-γ). Here, we identified a previously unrecognized role for interleukin-15 (IL-15) in red blood cell h...

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Bibliographic Details
Published in:Infection and Immunity 2007-05, Vol.75 (5), p.2630-2633
Main Authors: Mullarky, Isis K, Szaba, Frank M, Kummer, Lawrence W, Wilhelm, Lindsey B, Parent, Michelle A, Johnson, Lawrence L, Smiley, Stephen T
Format: Article
Language:English
Subjects:
Anemia - parasitology
Anemia - physiopathology
Animals
Biological and medical sciences
Bone Marrow Cells
Cells, Cultured
Erythropoiesis - drug effects
Fundamental and applied biological sciences. Psychology
Interferon-gamma - pharmacology
Interleukin-15 - metabolism
Mice
Mice, Inbred C57BL
Microbiology
Molecular Pathogenesis
STAT1 Transcription Factor - metabolism
Toxoplasma - pathogenicity
Toxoplasmosis, Animal - parasitology
Toxoplasmosis, Animal - physiopathology
Up-Regulation
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Summary:Impaired erythropoiesis causes anemia during genetic disorders, chronic disease, and infection. In studies of the underlying mechanisms researchers have increasingly focused on gamma interferon (IFN-γ). Here, we identified a previously unrecognized role for interleukin-15 (IL-15) in red blood cell homeostasis and demonstrated that IFN-γ and signal transducer and activator of transcription protein 1-dependent pathways up-regulate expression of IL-15 in vivo. These findings identified new therapeutic targets for anemia.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.01836-06