Isolation and characterization of the Saccharomyces cerevisiae XPT1 gene encoding xanthine phosphoribosyl transferase

A new Saccharomyces cerevisiae gene, XPT1, was isolated as a multicopy suppressor of a hypoxanthine phosphoribosyl transferase (HPRT) defect. Disruption of XPT1 affects xanthine utilization in vivo and results in a severe reduction of xanthine phosphoribosyl transferase (XPRT) activity while HPRT is...

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Bibliographic Details
Published in:Journal of Bacteriology 1999-05, Vol.181 (9), p.2984-2986
Main Authors: Guetsova, M.L, Crother, T.R, Taylor, M.W, Daignan-Fornier, B
Format: Article
Language:English
Subjects:
Bacteriology
Eukaryotic Cells
Genes
Genes, Fungal
Hypoxanthine Phosphoribosyltransferase - genetics
metabolism
mutagenesis
mutants
pentosyltransferases
Pentosyltransferases - genetics
Purines - metabolism
Saccharomyces cerevisiae
Saccharomyces cerevisiae - enzymology
Saccharomyces cerevisiae - genetics
structural genes
Suppression, Genetic
xanthine
Xanthine - metabolism
Yeast
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Summary:A new Saccharomyces cerevisiae gene, XPT1, was isolated as a multicopy suppressor of a hypoxanthine phosphoribosyl transferase (HPRT) defect. Disruption of XPT1 affects xanthine utilization in vivo and results in a severe reduction of xanthine phosphoribosyl transferase (XPRT) activity while HPRT is unaffected. We conclude that XPT1 encodes XPRT in yeast.
ISSN:0021-9193
1098-5530
1067-8832
DOI:10.1128/jb.181.9.2984-2986.1999