Role for Mycobacterium tuberculosis Membrane Vesicles in Iron Acquisition

Mycobacterium tuberculosis releases membrane vesicles packed with molecules that can modulate the immune response. Because environmental conditions often influence the production and content of bacterial vesicles, this study examined M. tuberculosis microvesicles released under iron limitation, a co...

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Bibliographic Details
Published in:Journal of Bacteriology 2014-03, Vol.196 (6), p.1250-1256
Main Authors: Prados-Rosales, Rafael, Weinrick, Brian C, Piqué, Daniel G, Jacobs, William R, Casadevall, Arturo, Rodriguez, G. Marcela
Format: Article
Language:English
Subjects:
Bacteria
Bacteriology
Environmental conditions
environmental factors
Exosomes - metabolism
immune response
Iron
Iron - metabolism
Membranes
Molecules
Mycobacterium tuberculosis
Mycobacterium tuberculosis - metabolism
Oxazoles - metabolism
Pathogens
Transport Vesicles - metabolism
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Summary:Mycobacterium tuberculosis releases membrane vesicles packed with molecules that can modulate the immune response. Because environmental conditions often influence the production and content of bacterial vesicles, this study examined M. tuberculosis microvesicles released under iron limitation, a common condition faced by pathogens inside the host. The findings indicate that M. tuberculosis increases microvesicle production in response to iron restriction and that these microvesicles contain mycobactin, which can serve as an iron donor and supports replication of iron-starved mycobacteria. Consequently, the results revealed a role of microvesicles in iron acquisition in M. tuberculosis, which can be critical for survival in the host.
ISSN:0021-9193
1098-5530
1067-8832
DOI:10.1128/JB.01090-13