Dissemination of Community-Acquired Methicillin-Resistant Staphylococcus aureus Clones in Northern Norway: Sequence Types 8 and 80 Predominate

Increasing frequencies of community-acquired methicillin-resistant Staphylcoccus aureus (MRSA) strain isolation have been reported from many countries. The overall prevalence of MRSA in Norway is still very low. MRSA isolates (n = 67) detected between 1995 and 2003 in northern Norway were analyzed b...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2005-05, Vol.43 (5), p.2118-2124
Main Authors: Hanssen, Anne-Merethe, Fossum, Aina, Mikalsen, Jarle, Halvorsen, Dag S, Bukholm, Geir, Sollid, Johanna U. Ericson
Format: Article
Language:English
Subjects:
Bacteriology
Biological and medical sciences
Community-Acquired Infections - epidemiology
Community-Acquired Infections - microbiology
Community-Acquired Infections - transmission
Fundamental and applied biological sciences. Psychology
Humans
Infectious diseases
Medical sciences
Methicillin Resistance
Microbial Sensitivity Tests
Microbiology
Miscellaneous
Molecular Epidemiology - methods
Norway - epidemiology
Phylogeny
Serotyping
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcal Infections - transmission
Staphylococcus aureus
Staphylococcus aureus - classification
Staphylococcus aureus - drug effects
Staphylococcus aureus - genetics
Staphylococcus aureus - isolation & purification
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Summary:Increasing frequencies of community-acquired methicillin-resistant Staphylcoccus aureus (MRSA) strain isolation have been reported from many countries. The overall prevalence of MRSA in Norway is still very low. MRSA isolates (n = 67) detected between 1995 and 2003 in northern Norway were analyzed by pulsed-field gel electrophoresis, multilocus sequence typing, and staphylococcal cassette chromosome mec (SCCmec) typing. Sixty-seven isolates were associated with 13 different sequence types. Two successful MRSA clones predominated. Sequence type 8 (ST8) (40%) and ST80 (19%) containing SCCmec type IV were detected in hospitals and communities in different geographic regions during a 7-year period. In general, there was a low level of antimicrobial resistance. Only 26% of the isolates were multiresistant. International epidemic clones were detected. The frequent findings of SCCmec type IV (91%) along with heterogeneous genetic backgrounds suggest a horizontal spread of SCCmec type IV among staphylococcal strains in parallel with the clonal spread of successful MRSA strains.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.43.5.2118-2124.2005