Polymorphisms in the Genes Encoding Chemokine Receptor 5, Interleukin-10, and Monocyte Chemoattractant Protein 1 Contribute to Cytomegalovirus Reactivation and Disease after Allogeneic Stem Cell Transplantation

We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2006-05, Vol.44 (5), p.1847-1850
Main Authors: Loeffler, Juergen, Steffens, Michael, Arlt, Eva-Maria, Toliat, Mohammad-Reza, Mezger, Markus, Suk, Anita, Wienker, Thomas F, Hebart, Holger, Nürnberg, Peter, Boeckh, Michael, Ljungman, Per, Trenschel, Rudolf, Einsele, Hermann
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Case-Control Studies
Chemokine CCL2 - genetics
Cytomegalovirus Infections - etiology
Cytomegalovirus Infections - genetics
Cytomegalovirus Infections - immunology
Female
Fundamental and applied biological sciences. Psychology
Human cytomegalovirus
Humans
Infectious diseases
Interleukin-10 - genetics
Male
Medical sciences
Medicin och hälsovetenskap
Microbiology
Middle Aged
Miscellaneous
Polymorphism, Single Nucleotide
Receptors, CCR5 - genetics
Risk Factors
Stem Cell Transplantation - adverse effects
Transplantation, Homologous
Virology
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Summary:We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis.
ISSN:0095-1137
1098-660X
1098-5530
DOI:10.1128/jcm.44.5.1847-1850.2006