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Polymorphisms in the Genes Encoding Chemokine Receptor 5, Interleukin-10, and Monocyte Chemoattractant Protein 1 Contribute to Cytomegalovirus Reactivation and Disease after Allogeneic Stem Cell Transplantation
We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of...
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| Published in: | Journal of Clinical Microbiology 2006-05, Vol.44 (5), p.1847-1850 |
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| Main Authors: | , , , , , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c678t-21818cf712e57e9b43649e37e796443b0408d35124792c5945a8b2afea818fd83 |
| container_end_page | 1850 |
| container_issue | 5 |
| container_start_page | 1847 |
| container_title | Journal of Clinical Microbiology |
| container_volume | 44 |
| creator | Loeffler, Juergen Steffens, Michael Arlt, Eva-Maria Toliat, Mohammad-Reza Mezger, Markus Suk, Anita Wienker, Thomas F Hebart, Holger Nürnberg, Peter Boeckh, Michael Ljungman, Per Trenschel, Rudolf Einsele, Hermann |
| description | We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis. |
| doi_str_mv | 10.1128/jcm.44.5.1847-1850.2006 |
| format | article |
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We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis.</description><identifier>ISSN: 0095-1137</identifier><identifier>EISSN: 1098-660X</identifier><identifier>EISSN: 1098-5530</identifier><identifier>DOI: 10.1128/jcm.44.5.1847-1850.2006</identifier><identifier>PMID: 16672419</identifier><identifier>CODEN: JCMIDW</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Case-Control Studies ; Chemokine CCL2 - genetics ; Cytomegalovirus Infections - etiology ; Cytomegalovirus Infections - genetics ; Cytomegalovirus Infections - immunology ; Female ; Fundamental and applied biological sciences. Psychology ; Human cytomegalovirus ; Humans ; Infectious diseases ; Interleukin-10 - genetics ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Microbiology ; Middle Aged ; Miscellaneous ; Polymorphism, Single Nucleotide ; Receptors, CCR5 - genetics ; Risk Factors ; Stem Cell Transplantation - adverse effects ; Transplantation, Homologous ; Virology</subject><ispartof>Journal of Clinical Microbiology, 2006-05, Vol.44 (5), p.1847-1850</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright © 2006, American Society for Microbiology 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c678t-21818cf712e57e9b43649e37e796443b0408d35124792c5945a8b2afea818fd83</citedby><cites>FETCH-LOGICAL-c678t-21818cf712e57e9b43649e37e796443b0408d35124792c5945a8b2afea818fd83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479205/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479205/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,3188,3189,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17768072$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16672419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1947032$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Loeffler, Juergen</creatorcontrib><creatorcontrib>Steffens, Michael</creatorcontrib><creatorcontrib>Arlt, Eva-Maria</creatorcontrib><creatorcontrib>Toliat, Mohammad-Reza</creatorcontrib><creatorcontrib>Mezger, Markus</creatorcontrib><creatorcontrib>Suk, Anita</creatorcontrib><creatorcontrib>Wienker, Thomas F</creatorcontrib><creatorcontrib>Hebart, Holger</creatorcontrib><creatorcontrib>Nürnberg, Peter</creatorcontrib><creatorcontrib>Boeckh, Michael</creatorcontrib><creatorcontrib>Ljungman, Per</creatorcontrib><creatorcontrib>Trenschel, Rudolf</creatorcontrib><creatorcontrib>Einsele, Hermann</creatorcontrib><title>Polymorphisms in the Genes Encoding Chemokine Receptor 5, Interleukin-10, and Monocyte Chemoattractant Protein 1 Contribute to Cytomegalovirus Reactivation and Disease after Allogeneic Stem Cell Transplantation</title><title>Journal of Clinical Microbiology</title><addtitle>J Clin Microbiol</addtitle><description>We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Chemokine CCL2 - genetics</subject><subject>Cytomegalovirus Infections - etiology</subject><subject>Cytomegalovirus Infections - genetics</subject><subject>Cytomegalovirus Infections - immunology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human cytomegalovirus</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Interleukin-10 - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptors, CCR5 - genetics</subject><subject>Risk Factors</subject><subject>Stem Cell Transplantation - adverse effects</subject><subject>Transplantation, Homologous</subject><subject>Virology</subject><issn>0095-1137</issn><issn>1098-660X</issn><issn>1098-5530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFk99u0zAUxiMEYmXwCsxcwNVS7MT_coM0hTGGNjGxTeLOct2T1ltiF9vd1NfkiXDXQtkF4ipWzu_7zvHJl6I4IHhMSCXf35hhTOmYjYmkoiSS4XGFMX9SjAhuZMk5_v60GGHcsJKQWuwVL2K8wZhQytjzYo9wLipKmlHx88L3q8GHxdzGISLrUJoDOgEHER0746fWzVA7h8HfWgfoGxhYJB8QO0SnLkHoYZkLJcGHSLspOvfOm1WCjUSnFLRJ2iV0EXyC7E5Q610KdrLMUPKoXSU_wEz3_s6GZcwNssDe6WS9e3D8aCPoCEh3uRs66ns_y8NZgy4TDKiFvkdXQbu46HObB9nL4lmn-wivts_94vrT8VX7uTz7enLaHp2VhguZyopIIk0nSAVMQDOhNacN1AJEwymtJ5hiOa0ZqahoKsMayrScVLoDnXXdVNb7RbnxjfewWE7UIthBh5Xy2qrtq9t8AsUEEw3JvPgnvwh-uhP9FpKGClxXWflho8zlAaYG8gZ1_9jgUcXZuZr5O0XWs2OWDd5tDYL_sYSY1GCjybvTDvwyKi6amgvG_wsSQahsONtdxgQfY4DuzzQEq3VE1Zf2XFGqmFpHVK0jqtYRzcrXf19mp9tmMgNvt4CORvdd_rrGxh0nBJdYrLfyZsPN7Wx-bwMoHQeV_4xd28wcbJhOe6VnIftcX1aY1JhgIUU-_AKPuAq4</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Loeffler, Juergen</creator><creator>Steffens, Michael</creator><creator>Arlt, Eva-Maria</creator><creator>Toliat, Mohammad-Reza</creator><creator>Mezger, Markus</creator><creator>Suk, Anita</creator><creator>Wienker, Thomas F</creator><creator>Hebart, Holger</creator><creator>Nürnberg, Peter</creator><creator>Boeckh, Michael</creator><creator>Ljungman, Per</creator><creator>Trenschel, Rudolf</creator><creator>Einsele, Hermann</creator><general>American Society for Microbiology</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20060501</creationdate><title>Polymorphisms in the Genes Encoding Chemokine Receptor 5, Interleukin-10, and Monocyte Chemoattractant Protein 1 Contribute to Cytomegalovirus Reactivation and Disease after Allogeneic Stem Cell Transplantation</title><author>Loeffler, Juergen ; Steffens, Michael ; Arlt, Eva-Maria ; Toliat, Mohammad-Reza ; Mezger, Markus ; Suk, Anita ; Wienker, Thomas F ; Hebart, Holger ; Nürnberg, Peter ; Boeckh, Michael ; Ljungman, Per ; Trenschel, Rudolf ; Einsele, Hermann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c678t-21818cf712e57e9b43649e37e796443b0408d35124792c5945a8b2afea818fd83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Chemokine CCL2 - genetics</topic><topic>Cytomegalovirus Infections - etiology</topic><topic>Cytomegalovirus Infections - genetics</topic><topic>Cytomegalovirus Infections - immunology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human cytomegalovirus</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Interleukin-10 - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptors, CCR5 - genetics</topic><topic>Risk Factors</topic><topic>Stem Cell Transplantation - adverse effects</topic><topic>Transplantation, Homologous</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Loeffler, Juergen</creatorcontrib><creatorcontrib>Steffens, Michael</creatorcontrib><creatorcontrib>Arlt, Eva-Maria</creatorcontrib><creatorcontrib>Toliat, Mohammad-Reza</creatorcontrib><creatorcontrib>Mezger, Markus</creatorcontrib><creatorcontrib>Suk, Anita</creatorcontrib><creatorcontrib>Wienker, Thomas F</creatorcontrib><creatorcontrib>Hebart, Holger</creatorcontrib><creatorcontrib>Nürnberg, Peter</creatorcontrib><creatorcontrib>Boeckh, Michael</creatorcontrib><creatorcontrib>Ljungman, Per</creatorcontrib><creatorcontrib>Trenschel, Rudolf</creatorcontrib><creatorcontrib>Einsele, Hermann</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Journal of Clinical Microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Loeffler, Juergen</au><au>Steffens, Michael</au><au>Arlt, Eva-Maria</au><au>Toliat, Mohammad-Reza</au><au>Mezger, Markus</au><au>Suk, Anita</au><au>Wienker, Thomas F</au><au>Hebart, Holger</au><au>Nürnberg, Peter</au><au>Boeckh, Michael</au><au>Ljungman, Per</au><au>Trenschel, Rudolf</au><au>Einsele, Hermann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms in the Genes Encoding Chemokine Receptor 5, Interleukin-10, and Monocyte Chemoattractant Protein 1 Contribute to Cytomegalovirus Reactivation and Disease after Allogeneic Stem Cell Transplantation</atitle><jtitle>Journal of Clinical Microbiology</jtitle><addtitle>J Clin Microbiol</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>44</volume><issue>5</issue><spage>1847</spage><epage>1850</epage><pages>1847-1850</pages><issn>0095-1137</issn><eissn>1098-660X</eissn><eissn>1098-5530</eissn><coden>JCMIDW</coden><abstract>We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis.</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>16672419</pmid><doi>10.1128/jcm.44.5.1847-1850.2006</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0095-1137 |
| ispartof | Journal of Clinical Microbiology, 2006-05, Vol.44 (5), p.1847-1850 |
| issn | 0095-1137 1098-660X 1098-5530 |
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| source | American Society for Microbiology; PubMed (Medline) |
| subjects | Adolescent Adult Aged Biological and medical sciences Case-Control Studies Chemokine CCL2 - genetics Cytomegalovirus Infections - etiology Cytomegalovirus Infections - genetics Cytomegalovirus Infections - immunology Female Fundamental and applied biological sciences. Psychology Human cytomegalovirus Humans Infectious diseases Interleukin-10 - genetics Male Medical sciences Medicin och hälsovetenskap Microbiology Middle Aged Miscellaneous Polymorphism, Single Nucleotide Receptors, CCR5 - genetics Risk Factors Stem Cell Transplantation - adverse effects Transplantation, Homologous Virology |
| title | Polymorphisms in the Genes Encoding Chemokine Receptor 5, Interleukin-10, and Monocyte Chemoattractant Protein 1 Contribute to Cytomegalovirus Reactivation and Disease after Allogeneic Stem Cell Transplantation |
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