Novel Human Rotavirus of Genotype G5P[6] Identified in a Stool Specimen from a Chinese Girl with Diarrhea

During a rotavirus surveillance conducted in Lulong County, Hebei Province, China, a total of 331 stool specimens collected in 2003 from children under 5 years old with diarrhea were screened. We identified a novel group A human rotavirus of genotype G5P[6]. Phylogenetic analysis confirmed that the...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2007-05, Vol.45 (5), p.1614-1617
Main Authors: Duan, Zhao-Jun, Li, Dan-Di, Zhang, Qing, Liu, Na, Huang, Can-Ping, Jiang, Xi, Jiang, Baomin, Glass, Roger, Steele, Duncan, Tang, Jing-Yu, Wang, Zhong-Shan, Fang, Zhao-Yin
Format: Article
Language:English
Subjects:
Biological and medical sciences
China
Diarrhea - virology
Feces - virology
Female
Fundamental and applied biological sciences. Psychology
Genes, Viral
Genotype
Human rotavirus
Humans
Infant
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
Molecular Sequence Data
Phylogeny
Population Surveillance
Rotavirus - genetics
Rotavirus - isolation & purification
Virology
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Summary:During a rotavirus surveillance conducted in Lulong County, Hebei Province, China, a total of 331 stool specimens collected in 2003 from children under 5 years old with diarrhea were screened. We identified a novel group A human rotavirus of genotype G5P[6]. Phylogenetic analysis confirmed that the VP7 protein of this newly identified strain, LL36755, was closely related to those of the G5 strains. As such, it has 95.4% homology with its counterparts in the porcine G5 strains C134 and CC117 at the amino acid sequence level. On the other hand, the VP4 protein of the LL36755 strain was 94.5% homologous to those of the porcine P[6] strains 134/04-10, 134/04-11, 221/04-7, and 221/04-13. Our findings indicate a dynamic interaction between human and porcine rotaviruses.
ISSN:0095-1137
1098-660X
1098-5530
DOI:10.1128/JCM.00032-07