Association between 16S-23S Internal Transcribed Spacer Sequence Groups of Mycobacterium avium Complex and Pulmonary Disease

Organisms within the Mycobacterium avium complex (MAC) may have differential virulence. We compared 33 subjects with MAC pulmonary disease to 75 subjects with a single positive culture without disease. M. avium isolates were significantly more likely to be associated with MAC pulmonary disease (odds...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2008-08, Vol.46 (8), p.2790-2793
Main Authors: Stout, Jason E, Hopkins, Gregory W, McDonald, Jay R, Quinn, Anita, Hamilton, Carol D, Reller, L. Barth, Frothingham, Richard
Format: Article
Language:English
Subjects:
Aged
Bacteriology
Biological and medical sciences
Case-Control Studies
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
DNA, Ribosomal Spacer - genetics
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Microbiology
Middle Aged
Miscellaneous
Mycobacteriology and Aerobic Actinomycetes
Mycobacterium avium - genetics
Mycobacterium avium - pathogenicity
Mycobacterium avium Complex - genetics
Mycobacterium avium Complex - pathogenicity
Phylogeny
Sequence Analysis, DNA
Tuberculosis, Pulmonary - microbiology
Virulence
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Summary:Organisms within the Mycobacterium avium complex (MAC) may have differential virulence. We compared 33 subjects with MAC pulmonary disease to 75 subjects with a single positive culture without disease. M. avium isolates were significantly more likely to be associated with MAC pulmonary disease (odds ratio = 5.14, 95% confidence interval = 1.25 to 22.73) than M. intracellulare.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.00719-08