An influenza A (H1N1) virus, closely related to swine influenza virus, responsible for a fatal case of human influenza

In July 1991, an influenza A virus, designated A/Maryland/12/91 (A/MD), was isolated from the bronchial secretions of a 27-year-old animal caretaker. He had been admitted to the hospital with bilateral pneumonia and died of acute respiratory distress syndrome 13 days later. Antigenic analyses with p...

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Bibliographic Details
Published in:Journal of Virology 1994-04, Vol.68 (4), p.2051-2058
Main Authors: Wentworth, D.E, Thompson, B.L, Xu, X, Regnery, H.L, Cooley, A.J, McGregor, M.W, Cox, N.J, Hinshaw, V.S
Format: Article
Language:English
Subjects:
Acute Disease
Adult
AGGLUTININE
AGLUTININAS
ANIMAL DE LABORATOIRE
ANIMALES DE LABORATORIO
Animals
Base Sequence
Bronchi - microbiology
CERDO
Cross Reactions
GENE
GENERO HUMANO
GENES
Genes, Viral - genetics
Genome, Viral
GENRE HUMAIN
Humans
Infant, Newborn
influenza A virus
Influenza A virus - genetics
Influenza A virus - immunology
Influenza A virus - pathogenicity
Influenza A Virus, H1N1 Subtype
Influenza, Human - epidemiology
Influenza, Human - microbiology
Influenza, Human - mortality
INFLUENZAVIRUS
INFLUENZAVIRUS PORCIN
Male
MAMIFEROS
MAMMIFERE
Maryland - epidemiology
Molecular Sequence Data
Nucleotide Mapping
Pneumonia, Viral - epidemiology
Pneumonia, Viral - microbiology
Pneumonia, Viral - mortality
PORCIN
PROTEINAS
PROTEINE
Respiratory Distress Syndrome, Newborn
RIESGOS OCUPACIONALES
RISQUE PROFESSIONNEL
SECUENCIA NUCLEICA
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
SEQUENCE NUCLEIQUE
Swine
VIROSE
VIROSIS
VIRUS
VIRUS DE LA INFLUENZA PORCINA
ZOONOSE
ZOONOSIS
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Description
Summary:In July 1991, an influenza A virus, designated A/Maryland/12/91 (A/MD), was isolated from the bronchial secretions of a 27-year-old animal caretaker. He had been admitted to the hospital with bilateral pneumonia and died of acute respiratory distress syndrome 13 days later. Antigenic analyses with postinfection ferret antisera and monoclonal antibodies to recent H1 swine hemagglutinins indicated that the hemagglutinin of this virus was antigenically related to, but distinguishable from, those of other influenza A (H1N1) viruses currently circulating in swine. Oligonucleotide mapping of total viral RNAs revealed differences between A/MD and other contemporary swine viruses. However, partial sequencing of each RNA segment of A/MD demonstrated that all segments were related to those of currently circulating swine viruses. Sequence analysis of the entire hemagglutinin, nucleoprotein, and matrix genes of A/MD revealed a high level of identity with other contemporary swine viruses. Our studies on A/MD emphasize that H1N1 viruses in pigs obviously continue to cross species barriers and infect humans
ISSN:0022-538X
1098-5514
DOI:10.1128/jvi.68.4.2051-2058.1994