Complete Genome Sequencing of a Novel Newcastle Disease Virus Isolate Circulating in Layer Chickens in the Dominican Republic

Newcastle disease virus (NDV) was isolated from an outbreak in layer chickens in the Dominican Republic in 2008. Infections with this isolate led to a 100% apparent case fatality rate in birds. Complete genome sequencing revealed that the isolate does not belong to any of the previously described ND...

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Bibliographic Details
Published in:Journal of Virology 2012-09, Vol.86 (17), p.9550-9550
Main Authors: Courtney, Sean C, Gomez, Dejelia, Susta, Leonardo, Hines, Nichole, Pedersen, Janice C, Miller, Patti J, Afonso, Claudio L
Format: Article
Language:English
Subjects:
amino acid sequences
Animals
Base Sequence
Biological and medical sciences
Chickens
disease outbreaks
Dominican Republic
Fundamental and applied biological sciences. Psychology
genome
Genome Announcements
Genome, Viral
genotype
hemagglutinins
laying hens
Microbiology
Miscellaneous
Molecular Sequence Data
mortality
Newcastle disease
Newcastle Disease - virology
Newcastle disease virus
Newcastle disease virus - classification
Newcastle disease virus - genetics
Newcastle disease virus - isolation & purification
nucleotide sequences
Poultry Diseases - virology
sialidase
viral fusion proteins
Virology
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Summary:Newcastle disease virus (NDV) was isolated from an outbreak in layer chickens in the Dominican Republic in 2008. Infections with this isolate led to a 100% apparent case fatality rate in birds. Complete genome sequencing revealed that the isolate does not belong to any of the previously described NDV genotypes. Similarly, large differences were observed in the amino acid sequence of the fusion and hemagglutinin-neuraminidase proteins in comparison with all known NDV genotypes, suggesting the existence of an unknown reservoir for NDV. The work presented here represents the first complete genome sequence of NDV in the Dominican Republic.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.01491-12