Galactose Stimulation of β-Galactosidase Induction in Galactokinaseless Mutants of Escherichia coli

Galactose stimulates the induction of β-galactosidase by thiomethylgalactoside in two galactokinaseless strains of Escherichia coli , one of which also lacks the galactoside permease of the lac operon. The stimulatory action of galactose results from the induction of a separate galactoside permease...

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Bibliographic Details
Published in:The Journal of biological chemistry 1967-02, Vol.242 (3), p.457
Main Authors: I. G. Leder, John W. Perry
Format: Article
Language:English
Online Access:Get full text
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Summary:Galactose stimulates the induction of β-galactosidase by thiomethylgalactoside in two galactokinaseless strains of Escherichia coli , one of which also lacks the galactoside permease of the lac operon. The stimulatory action of galactose results from the induction of a separate galactoside permease, probably identical with that induced by galactinol. Lactose, d -fucose, thiomethylgalactoside, and isopropylthiogalactoside do not act as inducers. In a galactose-fermenting strain, galactose inhibits rather than stimulates induction of β-galactosidase by thiomethylgalactoside.
ISSN:0021-9258
1083-351X