Alterations in basal nutrient metabolism increase resting energy expenditure in sickle cell disease

Departments of 1  Surgery and 2  Biochemistry, Vanderbilt University School of Medicine, Nashville 37232; and 3  Center for Nutrition and 4  Comprehensive Sickle Cell Center, Meharry Medical College, Nashville, Tennesse 37208 Basal rates of whole body protein, glucose, and lipid metabolism and resti...

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Published in:American journal of physiology: endocrinology and metabolism 1998-02, Vol.274 (2), p.E357-E364
Main Authors: Borel, Myfanwy J, Buchowski, Maciej S, Turner, Ernest A, Peeler, Benjamin B, Goldstein, Richard E, Flakoll, Paul J
Format: Article
Language:English
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Summary:Departments of 1  Surgery and 2  Biochemistry, Vanderbilt University School of Medicine, Nashville 37232; and 3  Center for Nutrition and 4  Comprehensive Sickle Cell Center, Meharry Medical College, Nashville, Tennesse 37208 Basal rates of whole body protein, glucose, and lipid metabolism and resting energy expenditure (REE) were measured in eight African-American sickle cell disease (SCD) patients and in six African-American controls. Catheters were placed 1 ) in an antecubital vein for stable isotope infusion and 2 ) in a heated hand vein for arterialized venous blood. Breath and blood were collected during the last 30 min of the 2.5-h study, and REE was measured by indirect calorimetry. REE [128 ± 5 vs. 111 ± 1 kJ · kg fat-free mass (FFM) 1 · day 1 ; P  
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.1998.274.2.E357