Restoration of insulin-like growth factor I action in skeletal muscle of old mice

1  Metabolic Biochemistry Laboratory, School of Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A 1S6; and 2  Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5 This study examined the effects of long-term chronic volu...

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Published in:American journal of physiology: endocrinology and metabolism 1998-09, Vol.275 (3), p.E525-E530
Main Authors: Willis, P. E, Chadan, S. G, Baracos, V, Parkhouse, W. S
Format: Article
Language:English
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Summary:1  Metabolic Biochemistry Laboratory, School of Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A 1S6; and 2  Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5 This study examined the effects of long-term chronic voluntary wheel exercise on the ability of insulin-like growth factor I (IGF-I) to stimulate rates of protein synthesis in the soleus muscle of old C57Bl/6 mice. Factors contributing to any changes in hormone action were analyzed at the level of hormone receptor binding, protein content, and gene expression. Chronic exercise resulted in an increased skeletal muscle mass (10-22%) and a 56% increase in IGF-I-stimulated rates of protein synthesis ( P  
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.1998.275.3.e525