Acute alcohol administration inhibits the refeeding response after starvation in rat skeletal muscle

1  Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB; 2  Department of Agriculture and Forestry, University of Aberdeen, Aberdeen AB24 5UA; 3  Department of Nutrition and Dietetics, King's College London, London SE1 9NN; and 4  Department of Medicine, Guys, Kings and St. Thomas' Scho...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2003-05, Vol.284 (5), p.E874-E882
Main Authors: Sneddon, A. A, Koll, M, Wallace, M. C, Jones, J, Miell, J. P, Garlick, P. J, Preedy, V. R
Format: Article
Language:English
Subjects:
Amino Acids - blood
Animal Feed
Animals
Carrier Proteins - metabolism
Ethanol - pharmacology
Fasting
Insulin - blood
Insulin-Like Growth Factor I - analysis
Male
Muscle Proteins - biosynthesis
Muscle, Skeletal - physiopathology
Osmolar Concentration
Phosphoproteins - metabolism
Rats
Rats, Wistar
Ribosomal Protein S6 Kinases, 70-kDa - metabolism
Starvation - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:1  Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB; 2  Department of Agriculture and Forestry, University of Aberdeen, Aberdeen AB24 5UA; 3  Department of Nutrition and Dietetics, King's College London, London SE1 9NN; and 4  Department of Medicine, Guys, Kings and St. Thomas' School of Medicine, King's Denmark Hill Campus, London SE5 9PJ, United Kingdom; and 5  Department of Surgery, State University of New York at Stony Brook, Stony Brook, New York 11794 This study determined whether an acute alcohol dose could inhibit the refeeding response in starved muscle. Rats starved for 24 h were pretreated with alcohol or saline before refeeding by intragastric or intravenous infusion of enteral diet (ENT), total parenteral nutrition (TPN), or saline. Refeeding by TPN or ENT stimulated increases in the fractional rate of protein synthesis ( k s ) in skeletal muscle. Alcohol prevented the increase in k s when refeeding occurred intragastrically (TPN or ENT) ( P  
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.00209.2002