Effect of milrinone on left ventricular relaxation and Ca2+ uptake function of cardiac sarcoplasmic reticulum

Second Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan Milrinone, a phosphodiesterase 3 (PDE3) inhibitor, is known to enhance left ventricular (LV) contractility by an inhibition of the breakdown of cAMP through the mechanism inhibiting PDE3....

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Published in:American journal of physiology. Heart and circulatory physiology 2000-10, Vol.279 (4), p.H1898
Main Authors: Yano, Masafumi, Kohno, Michihiro, Ohkusa, Tomoko, Mochizuki, Mamoru, Yamada, Jutaro, Kohno, Masateru, Hisaoka, Takayuki, Ono, Kaoru, Tanigawa, Taketo, Kobayashi, Shigeki, Matsuzaki, Masunori
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Language:eng ; jpn
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Summary:Second Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan Milrinone, a phosphodiesterase 3 (PDE3) inhibitor, is known to enhance left ventricular (LV) contractility by an inhibition of the breakdown of cAMP through the mechanism inhibiting PDE3. However, it is unclear whether milrinone also exerts positive lusitropy, like dobutamine. Here, we assessed the effects of milrinone on in vivo LV relaxation, as well as the Ca 2+ -ATPase activity and the Ca 2+ uptake function of the cardiac sarcoplasmic reticulum (SR), compared with the effect of dobutamine on those functions. After dobutamine (3 µg · kg 1 · min 1 ) was administered, the peak value of the first derivative of LV pressure (+dP/d t ) increased by 46%, whereas the time constant ( ) of LV pressure decay decreased by 6.9%, respectively. After milrinone (10 µg/kg) was administered, the peak +dP/d t increased to a similar extent as dobutamine (46%), whereas  decreased much more than dobutamine (19.9%; P  
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.2000.279.4.h1898