Aldosterone induces a vascular inflammatory phenotype in the rat heart

• Published in: American journal of physiology. Heart and circulatory physiology 2002-11, Vol.283 (5), p.H1802-H1810
• Main Authors: Rocha, Ricardo, Rudolph, Amy E, Frierdich, Gregory E, Nachowiak, Denise A, Kekec, Beverly K, Blomme, Eric A. G, McMahon, Ellen G, Delyani, John A
• Format: Article
• Language: English
• Subjects: Aldosterone - pharmacology; Animals; Blood Pressure; Chemokine CCL2 - genetics; Coronary Vessels - drug effects; Coronary Vessels - immunology; Cyclooxygenase 2; Endomyocardial Fibrosis - immunology; Endomyocardial Fibrosis - pathology; Gene Expression - immunology; Hypertension - immunology; Hypertension - pathology; Immunohistochemistry; In Situ Hybridization; Intercellular Adhesion Molecule-1 - analysis; Isoenzymes - genetics; Male; Myocardium - chemistry; Myocardium - immunology; Myocardium - pathology; Osteopontin; Phenotype; Prostaglandin-Endoperoxide Synthases - genetics; Rats; Rats, Sprague-Dawley; Sialoglycoproteins - analysis; Sialoglycoproteins - genetics; Spironolactone - analogs & derivatives; Spironolactone - pharmacology; Vascular Cell Adhesion Molecule-1 - analysis; Vasculitis - chemically induced; Vasculitis - immunology; Vasculitis - pathology
• ISSN: 0363-6135; 1522-1539
• DOI: 10.1152/ajpheart.01096.2001

1  Division of Cardiovascular and Metabolic Diseases and 2  Division of Global Toxicology, Pharmacia Corporation, Skokie, Illinois 60077 and St. Louis, Missouri 63141 Vascular inflammation was examined as a potential mechanism of aldosterone-mediated myocardial injury in uninephrectomized rats receiving 1% NaCl-0.3% KCl to drink for 1, 2, or 4 wk and 1 ) vehicle, 2 ) aldosterone infusion (0.75 µg/h), or 3 ) aldosterone infusion (0.75 µg/h) plus the selective aldosterone blocker eplerenone (100 mg · kg 1 · day 1 ). Aldosterone induced severe hypertension at 4 wk [systolic blood pressure (SBP), 210 ± 3 mmHg vs. vehicle, 131 ± 2 mmHg, P