Rhinovirus-mediated changes in airway smooth muscle responsiveness: induced autocrine role of interleukin-1beta

Divisions of 1  Pulmonary Medicine and 2  Immunologic and Infectious Diseases, Joseph Stokes, Jr. Research Institute, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 An important interplay exists between specific viral res...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 1999-07, Vol.277 (1), p.13
Main Authors: Hakonarson, Hakon, Carter, Carrie, Maskeri, Neil, Hodinka, Richard, Grunstein, Michael M
Format: Article
Language:English
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Summary:Divisions of 1  Pulmonary Medicine and 2  Immunologic and Infectious Diseases, Joseph Stokes, Jr. Research Institute, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 An important interplay exists between specific viral respiratory pathogens, most commonly rhinovirus (RV), and altered airway responsiveness in the development and exacerbations of asthma. Given that RV infection reportedly induces the release of various cytokines in different cell types and that the reported effects of RV on airway smooth muscle (ASM) responsiveness are highly comparable to those obtained in ASM exposed to the proinflammatory cytokine interleukin (IL)-1 , this study examined whether RV (serotype 16)-mediated pertubations in ASM responsiveness are mechanistically coupled to altered induced expression and action of IL-1 in RV-exposed isolated rabbit and human ASM tissue and cultured cells. Relative to control tissues, ASM inoculated with RV exhibited significantly increased maximal isometric contractility to ACh ( P  
ISSN:1040-0605
1522-1504
DOI:10.1152/ajplung.1999.277.1.L13