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Prenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring

K. Muneoka, M. Mikuni, T. Ogawa, K. Kitera, K. Kamei, M. Takigawa and K. Takahashi Department of Neuropsychiatry, Kagoshima University Faculty of Medicine, Japan. In this study, it has been clearly demonstrated that prenatal dexamethasone treatment (Dex; 0.05 mg/kg on gestational days 17, 18, and 19...

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Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1997-11, Vol.273 (5), p.1669-R1675
Main Authors: Muneoka, Katsumasa, Mikuni, Masahiko, Ogawa, Tetsuo, Kitera, Katsuki, Kamei, Kenji, Takigawa, Morikuni, Takahashi, Kiyohisa
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cited_by cdi_FETCH-LOGICAL-c466t-5f97a83351ba379fdfd05a054bcdba58e43c000d62e58505cf4e41e52c9d67443
cites cdi_FETCH-LOGICAL-c466t-5f97a83351ba379fdfd05a054bcdba58e43c000d62e58505cf4e41e52c9d67443
container_end_page R1675
container_issue 5
container_start_page 1669
container_title American journal of physiology. Regulatory, integrative and comparative physiology
container_volume 273
creator Muneoka, Katsumasa
Mikuni, Masahiko
Ogawa, Tetsuo
Kitera, Katsuki
Kamei, Kenji
Takigawa, Morikuni
Takahashi, Kiyohisa
description K. Muneoka, M. Mikuni, T. Ogawa, K. Kitera, K. Kamei, M. Takigawa and K. Takahashi Department of Neuropsychiatry, Kagoshima University Faculty of Medicine, Japan. In this study, it has been clearly demonstrated that prenatal dexamethasone treatment (Dex; 0.05 mg/kg on gestational days 17, 18, and 19) resulted in the significant reductions of 5-hydroxytryptamine (5-HT) turnover in four brain regions, including the neocortex, hippocampus, hypothalamus, and midbrain + pons-medulla (M + P-M) but not in the striatum in the offspring at 3 and 14 wk of life, as well as dopamine turnover in the hypothalamus. [3H]paroxetine binding densities were increased in the hypothalamus and M + P-M at 14 wk of life, which corresponded to increased 5-HT contents in both regions. On the other hand, significantly lower norepinephrine contents in the neocortex and hippocampus were observed in the Dex group compared with the control group at 14 wk of life. In addition, the exposure to new environmental condition elevated blood corticosterone levels and enhanced behavioral activities to a greater extent in the Dex group than in controls at 7 wk of life, suggesting that elevated glucocorticoid levels during the pregnancy mimicked prenatal mild stress, producing developmental alterations in brain monoamine metabolism, endocrine response, and behavior in adult offspring.
doi_str_mv 10.1152/ajpregu.1997.273.5.r1669
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Muneoka, M. Mikuni, T. Ogawa, K. Kitera, K. Kamei, M. Takigawa and K. Takahashi Department of Neuropsychiatry, Kagoshima University Faculty of Medicine, Japan. In this study, it has been clearly demonstrated that prenatal dexamethasone treatment (Dex; 0.05 mg/kg on gestational days 17, 18, and 19) resulted in the significant reductions of 5-hydroxytryptamine (5-HT) turnover in four brain regions, including the neocortex, hippocampus, hypothalamus, and midbrain + pons-medulla (M + P-M) but not in the striatum in the offspring at 3 and 14 wk of life, as well as dopamine turnover in the hypothalamus. [3H]paroxetine binding densities were increased in the hypothalamus and M + P-M at 14 wk of life, which corresponded to increased 5-HT contents in both regions. On the other hand, significantly lower norepinephrine contents in the neocortex and hippocampus were observed in the Dex group compared with the control group at 14 wk of life. 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title Prenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring
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