Canine intrinsic cardiac neurons involved in cardiac regulation possess NK1, NK2, and NK3 receptors

1  Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7; 2  Department of Pharmacology, College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614-0577; and 3  Department of Physiology, University of South A...

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Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1998-11, Vol.275 (5), p.1683
Main Authors: Thompson, G. W, Hoover, D. B, Ardell, J. L, Armour, J. A
Format: Article
Language:English
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Summary:1  Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7; 2  Department of Pharmacology, College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614-0577; and 3  Department of Physiology, University of South Alabama, Mobile, Alabama 36688-0002 To determine whether intrinsic cardiac neurons involved in cardiac regulation possess neurokinin (NK) receptor subtypes, we administered selective NK receptor agonists individually (100 µM; 0.1 ml) into the coronary arterial blood supply of right atrial intrinsic cardiac neurons of 18 anesthetized dogs. The selective NK 1 receptor agonist [Sar 9 ,Met(O 2 ) 11 ]-substance P depressed the spontaneous activity of right atrial neurons (26.7 ± 6.7 to 13.0 ± 4.0 impulses/min; P  
ISSN:0363-6119
1522-1490
DOI:10.1152/ajpregu.1998.275.5.r1683