Neuroendocrine and renal effects of intravascular volume expansion in compensated heart failure

1  Danish Aerospace Medical Centre of Research, National University Hospital (Rigshospitalet), DK-2200 Copenhagen; 2  Department of Physiology and Pharmacology, University of Southern Denmark, DK-5000 Odense; 3  Department of Medical Physiology, Panum Institute, University of Copenhagen, DK-2200 Cop...

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Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2001-08, Vol.281 (2), p.459-R467
Main Authors: Gabrielsen, Anders, Bie, Peter, Holstein-Rathlou, Niels Henrik, Christensen, Niels Juel, Warberg, Jorgen, Dige-Petersen, Harriet, Frandsen, Erik, Galatius, Soren, Pump, Bettina, Sorensen, Vibeke B, Kastrup, Jens, Norsk, Peter
Format: Article
Language:English
Subjects:
Aldosterone - blood
Angiotensin II - blood
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Atrial Natriuretic Factor - blood
Blood Pressure - physiology
Blood Volume - physiology
Cardiac Output, Low - physiopathology
Enzyme Inhibitors - pharmacology
Fluid Shifts - physiology
Glomerular Filtration Rate - physiology
Heart Rate - physiology
Humans
Immersion
Kidney - physiopathology
Male
Middle Aged
Natriuresis - physiology
Sodium - metabolism
Space life sciences
Urine - chemistry
Vasopressins - blood
Water-Electrolyte Balance - physiology
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Summary:1  Danish Aerospace Medical Centre of Research, National University Hospital (Rigshospitalet), DK-2200 Copenhagen; 2  Department of Physiology and Pharmacology, University of Southern Denmark, DK-5000 Odense; 3  Department of Medical Physiology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen; 4  Department of Internal Medicine and Endocrinology, Herlev Hospital, University of Copenhagen, DK-2730 Herlev; 5  Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, University of Copenhagen, DK-2600 Glostrup; and 6  Department of Cardiology, The Heart Centre, National University Hospital (Rigshospitalet), DK-2100 Copenhagen, Denmark To examine if the neuroendocrine link between volume sensing and renal function is preserved in compensated chronic heart failure [HF, ejection fraction 0.29 ± 0.03 (mean ± SE)] we tested the hypothesis that intravascular and central blood volume expansion by 3 h of water immersion (WI) elicits a natriuresis. In HF, WI suppressed ANG II and aldosterone (Aldo) concentrations, increased the release of atrial natriuretic peptide (ANP), and elicited a natriuresis ( P  
ISSN:0363-6119
1522-1490
DOI:10.1152/ajpregu.2001.281.2.r459