Ventilation-perfusion alterations after smoke inhalation injury in an ovine model

• Published in: Journal of applied physiology (1985) 1996-11, Vol.81 (5), p.2250-2259
• Main Authors: Shimazu, Takeshi, Yukioka, Tetsuo, Ikeuchi, Hisashi, Mason, Arthur D., Jr, Wagner, Peter D, Pruitt, Basil A., Jr
• Format: Article
• Language: English
• Subjects: Airway Resistance - physiology; Anesthesia, General; Animals; Biological and medical sciences; Blood Pressure - physiology; Carboxyhemoglobin - metabolism; Central Venous Pressure - physiology; Gas Chromatography-Mass Spectrometry; Lung Compliance - physiology; Male; Medical sciences; Pneumology; Respiratory system : syndromes and miscellaneous diseases; Sheep; Smoke Inhalation Injury - physiopathology; Time Factors; Ventilation-Perfusion Ratio - physiology
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.1996.81.5.2250

Takeshi Shimazu, Tetsuo Yukioka, Hisashi Ikeuchi, Arthur D. Mason Jr., Peter D. Wagner, and Basil A. Pruitt Jr. United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234-5012; Department of Traumatology, Osaka University Medical School, Osaka 565; Department of Traumatology and Critical Care Medicine, Kyorin University School of Medicine, Tokyo 181, Japan; and Department of Medicine, University of California, San Diego, La Jolla, California 92093-0623 Received 24 July 1995; accepted in final form 24 June 1996. Shimazu, Takeshi, Tetsuo Yukioka, Hisashi Ikeuchi, Arthur D. Mason, Jr., Peter D. Wagner, and Basil A. Pruitt, Jr. Ventilation-perfusion alterations after smoke inhalation injury in an ovine model. J. Appl. Physiol. 81(5): 2250-2259, 1996. To study the pathophysiological mechanism of progressive hypoxemia after smoke inhalation injury, alterations in ventilation-perfusion ratio ( A / ) were studied in an ovine model by using the multiple inert gas elimination technique. Because ethane was detected in expired gas of some sheep, we replaced ethane with krypton, which was a unique application of the multiple inert gas elimination technique when one of the experimental gases is present in the inspirate. Severity-related changes were studied 24 h after injury in control and mild, moderate, and severe inhalation injury groups. Time-related changes were studied in controls and sheep with moderate injury at 6, 12, 24, and 72 h. Arterial P O 2 decreased progressively with severity of injury as well as with time. In smoke-exposed animals, blood flow was recruited to low A / compartment (0