Nociceptive atrophy of the rat soleus muscle induced by bone fracture: a morphometric study

Gisela Zacha ová, Helena Knotková-Urbancová, Pavel Hník, and Tomá Soukup Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic Received 6 February 1996; accepted in final form 30 September 1996. Zacha ová, Gisela, Helena Knotková-Urbancová, Pavel Hník, and...

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Published in:Journal of applied physiology (1985) 1997-02, Vol.82 (2), p.552-557
Main Authors: Knotkova-Urbancova, Helena, Hnik, Pavel
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Bone and Bones - pathology
Fractures, Bone - pathology
Injuries of the limb. Injuries of the spine
Male
Medical sciences
Muscle, Skeletal - pathology
Muscular Atrophy - pathology
Rats
Rats, Wistar
Traumas. Diseases due to physical agents
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Summary:Gisela Zacha ová, Helena Knotková-Urbancová, Pavel Hník, and Tomá Soukup Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic Received 6 February 1996; accepted in final form 30 September 1996. Zacha ová, Gisela, Helena Knotková-Urbancová, Pavel Hník, and Tomá Soukup. Nociceptive atrophy of the rat soleus muscle induced by bone fracture: a morphometric study. J. Appl. Physiol. 82(2): 552-557, 1997. Reflex atrophy of the soleus muscle induced by ipsilateral metatarsal bone fracture in Sagatal-anesthetized adult male rats was studied by using two-dimensional stereological methods 7 days after the operation. When compared with contralateral solei, the wet weight of the experimental soleus muscles was decreased by ~24% and the area of the entire muscle section by ~29%. In atrophied solei, the number of type 1 fibers was lower by ~8%, resulting in lower total number of fibers (by ~6%). This indicates that slow motor units might be more sensitive to nociceptive stimulation. However, with respect to the fiber area, the reflex atrophy induced by metatarsal bone fracture in the rat soleus muscle resembles simple atrophy after 7 days, as the mean muscle fiber area was decreased by ~26% with no significant difference between atrophy in type 1 and type 2a fibers (by 27.3 and 23.0%, respectively). muscle atrophy; muscle histochemistry; muscle two-dimensional stereology; muscle fiber types; pain 0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.1997.82.2.552