Effects of training and a single session of exercise on lipids and apolipoproteins in hypercholesterolemic men

• Published in: Journal of applied physiology (1985) 1997-12, Vol.83 (6), p.2019-2028
• Main Authors: Crouse, Stephen F, O'Brien, Barbara C, Grandjean, Peter W, Lowe, Robert C, Rohack, J. James, Green, John S
• Format: Article
• Language: English
• Subjects: Adult; Apolipoproteins - blood; Biological and medical sciences; Body Composition - physiology; Cholesterol, HDL - blood; Diet; Errors of metabolism; Exercise - physiology; Humans; Hypercholesterolemia - blood; Lipids (lysosomal enzyme disorders, storage diseases); Lipids - blood; Male; Medical sciences; Metabolic diseases; Physical Education and Training; Time Factors; Triglycerides - blood
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.1997.83.6.2019

Stephen F. Crouse 1 , Barbara C. O'Brien 2 , Peter W. Grandjean 1 , Robert C. Lowe 3 , J. James Rohack 4 , and John S. Green 1 1  Applied Exercise Science Laboratory, Department of Health and Kinesiology, 2  Department of Biochemistry/Biophysics, and 4  College of Medicine, Health Science Center, Texas A & M University, College Station, Texas 77843; and 3  Health Management Center, Baptist Medical Center, Little Rock, Arkansas 72199 Received 21 January 1997; accepted in final form 22 July 1997. Crouse, Stephen F., Barbara C. O'Brien, Peter W. Grandjean, Robert C. Lowe, J. James Rohack, and John S. Green. Effects of training and a single session of exercise on lipids and apolipoproteins in hypercholesterolemic men. J. Appl. Physiol. 83(6): 2019-2028, 1997. To differentiate between transient (acute) and training (chronic) effects of exercise at two different intensities on blood lipids and apolipoproteins (apo), 26 hypercholesterolemic men (cholesterol = 258 mg/dl, age = 47 yr, weight = 81.9 kg) trained three times per week for 24 wk, 350 kcal/session at high (80% maximal O 2 uptake, n  = 12) or moderate (50% maximal O 2 uptake, n  = 14) intensity. Serum lipid and apolipoprotein (apo) concentrations (plasma volume adjusted) were measured before and immediately, 24, and 48 h after exercise on four different occasions corresponding to 0, 8, 16, and 24 wk of training. Data were analyzed using three-way repeated-measures multivariate analysis of variance followed by analysis of variance and Duncan's procedures (  = 0.05). A transient 6% rise in low-density-lipoprotein cholesterol measured before training at the 24-h time point was no longer evident after training. Triglycerides fell and total cholesterol, high-density-lipoprotein cholesterol (HDL-C), HDL 3 -C, apo A-I, and apo B rose 24-48 h after exercise regardless of training or intensity. Total cholesterol, HDL 3 -C, apo A-I, and apo B were lower and HDL 2 -C was higher after training than before training. Thus exercise training and a single session of exercise exert distinct and interactive effects on lipids and apolipoproteins. These results support the practice of training at least every other day to obtain optimal exercise benefits. lipoproteins; high-density-lipoprotein cholesterol; low-density-lipoprotein cholesterol; triglyceride 0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society