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Integrated response of the upper and lower respiratory tract of asthmatic subjects to frigid air
Division of Pulmonary and Critical Care Medicine, University Hospitals of Cleveland, and Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 To evaluate the influence of cold air hyperpnea on integrated upper and lower airway behavior, 22 asthmatic volun...
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| Published in: | Journal of applied physiology (1985) 2000-03, Vol.88 (3), p.1043-1050 |
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| Main Authors: | , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c447t-7d9fdccf59681bdda94d81a33eb2a8cd81f676482e003fe591a741ef63c0860a3 |
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| cites | cdi_FETCH-LOGICAL-c447t-7d9fdccf59681bdda94d81a33eb2a8cd81f676482e003fe591a741ef63c0860a3 |
| container_end_page | 1050 |
| container_issue | 3 |
| container_start_page | 1043 |
| container_title | Journal of applied physiology (1985) |
| container_volume | 88 |
| creator | McLane, Melissa L Nelson, Jo Ann Lenner, K. A Hejal, Rana Kotaru, Chakradhar Skowronski, Mary Coreno, Albert Lane, Elizabeth McFadden, E. R., Jr |
| description | Division of Pulmonary and Critical Care Medicine, University
Hospitals of Cleveland, and Department of Medicine, Case Western
Reserve University School of Medicine, Cleveland, Ohio 44106
To evaluate the influence of cold air hyperpnea on
integrated upper and lower airway behavior, 22 asthmatic volunteers
hyperventilated through their mouths (OHV) and noses (NHV) while
pulmonary and nasal function were determined individually and in
combination. In the isolated studies, OHV at a minute ventilation of 65 ± 3 l/min lowered the 1-s forced expiratory volume (FEV 1 )
24 ± 2% ( P |
| doi_str_mv | 10.1152/jappl.2000.88.3.1043 |
| format | article |
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Hospitals of Cleveland, and Department of Medicine, Case Western
Reserve University School of Medicine, Cleveland, Ohio 44106
To evaluate the influence of cold air hyperpnea on
integrated upper and lower airway behavior, 22 asthmatic volunteers
hyperventilated through their mouths (OHV) and noses (NHV) while
pulmonary and nasal function were determined individually and in
combination. In the isolated studies, OHV at a minute ventilation of 65 ± 3 l/min lowered the 1-s forced expiratory volume (FEV 1 )
24 ± 2% ( P < 0.001) and NHV (40 l/min) induced a 31 ± 9% ( P < 0.001) increase in nasal resistance (NR). In the
combined studies, oral hyperpnea reduced the FEV 1
( FEV 1 26 ± 2%, P < 0.001) and evoked a
significant rise in NR ( NR 26 ± 9%, P = 0.01). In
contrast, NHV only affected the upper airway. NR rose 33 ± 9% ( P = 0.01), but airway caliber did not change
( FEV 1 2%, P = 0.27). The results of this
investigation demonstrate that increasing the transfer of heat and
water in the lower respiratory tract alters bronchial and nasal
function in a linked fashion. Forcing the nose to augment its
heat-exchanging activity, however, reduces nasal caliber but has no
effect on the intrathoracic airways.
cold air; asthma; hyperpnea; nasal function; airway function</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.2000.88.3.1043</identifier><identifier>PMID: 10710402</identifier><language>eng</language><publisher>United States: Am Physiological Soc</publisher><subject>Acclimatization - physiology ; Adult ; Air ; Airway Resistance - physiology ; Asthma - physiopathology ; Body Temperature Regulation - physiology ; Bronchi - physiopathology ; Cold Temperature - adverse effects ; Female ; Forced Expiratory Volume - physiology ; Humans ; Hyperventilation - physiopathology ; Male ; Nasal Cavity - physiology ; Respiratory Mechanics - physiology</subject><ispartof>Journal of applied physiology (1985), 2000-03, Vol.88 (3), p.1043-1050</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-7d9fdccf59681bdda94d81a33eb2a8cd81f676482e003fe591a741ef63c0860a3</citedby><cites>FETCH-LOGICAL-c447t-7d9fdccf59681bdda94d81a33eb2a8cd81f676482e003fe591a741ef63c0860a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10710402$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McLane, Melissa L</creatorcontrib><creatorcontrib>Nelson, Jo Ann</creatorcontrib><creatorcontrib>Lenner, K. A</creatorcontrib><creatorcontrib>Hejal, Rana</creatorcontrib><creatorcontrib>Kotaru, Chakradhar</creatorcontrib><creatorcontrib>Skowronski, Mary</creatorcontrib><creatorcontrib>Coreno, Albert</creatorcontrib><creatorcontrib>Lane, Elizabeth</creatorcontrib><creatorcontrib>McFadden, E. R., Jr</creatorcontrib><title>Integrated response of the upper and lower respiratory tract of asthmatic subjects to frigid air</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Division of Pulmonary and Critical Care Medicine, University
Hospitals of Cleveland, and Department of Medicine, Case Western
Reserve University School of Medicine, Cleveland, Ohio 44106
To evaluate the influence of cold air hyperpnea on
integrated upper and lower airway behavior, 22 asthmatic volunteers
hyperventilated through their mouths (OHV) and noses (NHV) while
pulmonary and nasal function were determined individually and in
combination. In the isolated studies, OHV at a minute ventilation of 65 ± 3 l/min lowered the 1-s forced expiratory volume (FEV 1 )
24 ± 2% ( P < 0.001) and NHV (40 l/min) induced a 31 ± 9% ( P < 0.001) increase in nasal resistance (NR). In the
combined studies, oral hyperpnea reduced the FEV 1
( FEV 1 26 ± 2%, P < 0.001) and evoked a
significant rise in NR ( NR 26 ± 9%, P = 0.01). In
contrast, NHV only affected the upper airway. NR rose 33 ± 9% ( P = 0.01), but airway caliber did not change
( FEV 1 2%, P = 0.27). The results of this
investigation demonstrate that increasing the transfer of heat and
water in the lower respiratory tract alters bronchial and nasal
function in a linked fashion. Forcing the nose to augment its
heat-exchanging activity, however, reduces nasal caliber but has no
effect on the intrathoracic airways.
cold air; asthma; hyperpnea; nasal function; airway function</description><subject>Acclimatization - physiology</subject><subject>Adult</subject><subject>Air</subject><subject>Airway Resistance - physiology</subject><subject>Asthma - physiopathology</subject><subject>Body Temperature Regulation - physiology</subject><subject>Bronchi - physiopathology</subject><subject>Cold Temperature - adverse effects</subject><subject>Female</subject><subject>Forced Expiratory Volume - physiology</subject><subject>Humans</subject><subject>Hyperventilation - physiopathology</subject><subject>Male</subject><subject>Nasal Cavity - physiology</subject><subject>Respiratory Mechanics - physiology</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNp1kMFu1DAURS0EotPCHyDkFWKT8Bw7sbNEFaWVKrEpa-OxnyceZcbBdtTO35MwFYIFq3eld-5dHELeMagZa5tPezNNY90AQK1UzWsGgr8gm-XVVKwD9pJslGyhkq2SF-Qy5z0AE6Jlr8kFA7ng0GzIj7tjwV0yBR1NmKd4zEijp2VAOk8TJmqOjo7xcUnrPyxoTCdakrFlBU0uw8GUYGmet3u0JdMSqU9hFxw1Ib0hr7wZM759vlfk-82Xh-vb6v7b17vrz_eVFUKWSrreO2t923eKbZ0zvXCKGc5x2xhll-w72QnVIAD32PbMSMHQd9yC6sDwK_LhvDul-HPGXPQhZIvjaI4Y56wl9B2DRi6gOIM2xZwTej2lcDDppBno1az-bVavZrVSmuvV7FJ7_7w_bw_o_iqdVS7AxzMwhN3wGBLqaTjlEMe4O62T_2yJ_6M38zg-4FNZO38qenKe_wIjn5ia</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>McLane, Melissa L</creator><creator>Nelson, Jo Ann</creator><creator>Lenner, K. A</creator><creator>Hejal, Rana</creator><creator>Kotaru, Chakradhar</creator><creator>Skowronski, Mary</creator><creator>Coreno, Albert</creator><creator>Lane, Elizabeth</creator><creator>McFadden, E. R., Jr</creator><general>Am Physiological Soc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000301</creationdate><title>Integrated response of the upper and lower respiratory tract of asthmatic subjects to frigid air</title><author>McLane, Melissa L ; Nelson, Jo Ann ; Lenner, K. A ; Hejal, Rana ; Kotaru, Chakradhar ; Skowronski, Mary ; Coreno, Albert ; Lane, Elizabeth ; McFadden, E. R., Jr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-7d9fdccf59681bdda94d81a33eb2a8cd81f676482e003fe591a741ef63c0860a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Acclimatization - physiology</topic><topic>Adult</topic><topic>Air</topic><topic>Airway Resistance - physiology</topic><topic>Asthma - physiopathology</topic><topic>Body Temperature Regulation - physiology</topic><topic>Bronchi - physiopathology</topic><topic>Cold Temperature - adverse effects</topic><topic>Female</topic><topic>Forced Expiratory Volume - physiology</topic><topic>Humans</topic><topic>Hyperventilation - physiopathology</topic><topic>Male</topic><topic>Nasal Cavity - physiology</topic><topic>Respiratory Mechanics - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McLane, Melissa L</creatorcontrib><creatorcontrib>Nelson, Jo Ann</creatorcontrib><creatorcontrib>Lenner, K. A</creatorcontrib><creatorcontrib>Hejal, Rana</creatorcontrib><creatorcontrib>Kotaru, Chakradhar</creatorcontrib><creatorcontrib>Skowronski, Mary</creatorcontrib><creatorcontrib>Coreno, Albert</creatorcontrib><creatorcontrib>Lane, Elizabeth</creatorcontrib><creatorcontrib>McFadden, E. R., Jr</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McLane, Melissa L</au><au>Nelson, Jo Ann</au><au>Lenner, K. A</au><au>Hejal, Rana</au><au>Kotaru, Chakradhar</au><au>Skowronski, Mary</au><au>Coreno, Albert</au><au>Lane, Elizabeth</au><au>McFadden, E. R., Jr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Integrated response of the upper and lower respiratory tract of asthmatic subjects to frigid air</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>88</volume><issue>3</issue><spage>1043</spage><epage>1050</epage><pages>1043-1050</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><abstract>Division of Pulmonary and Critical Care Medicine, University
Hospitals of Cleveland, and Department of Medicine, Case Western
Reserve University School of Medicine, Cleveland, Ohio 44106
To evaluate the influence of cold air hyperpnea on
integrated upper and lower airway behavior, 22 asthmatic volunteers
hyperventilated through their mouths (OHV) and noses (NHV) while
pulmonary and nasal function were determined individually and in
combination. In the isolated studies, OHV at a minute ventilation of 65 ± 3 l/min lowered the 1-s forced expiratory volume (FEV 1 )
24 ± 2% ( P < 0.001) and NHV (40 l/min) induced a 31 ± 9% ( P < 0.001) increase in nasal resistance (NR). In the
combined studies, oral hyperpnea reduced the FEV 1
( FEV 1 26 ± 2%, P < 0.001) and evoked a
significant rise in NR ( NR 26 ± 9%, P = 0.01). In
contrast, NHV only affected the upper airway. NR rose 33 ± 9% ( P = 0.01), but airway caliber did not change
( FEV 1 2%, P = 0.27). The results of this
investigation demonstrate that increasing the transfer of heat and
water in the lower respiratory tract alters bronchial and nasal
function in a linked fashion. Forcing the nose to augment its
heat-exchanging activity, however, reduces nasal caliber but has no
effect on the intrathoracic airways.
cold air; asthma; hyperpnea; nasal function; airway function</abstract><cop>United States</cop><pub>Am Physiological Soc</pub><pmid>10710402</pmid><doi>10.1152/jappl.2000.88.3.1043</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 2000-03, Vol.88 (3), p.1043-1050 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_highwire_physiology_jap_88_3_1043 |
| source | American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list); American Physiological Society Free |
| subjects | Acclimatization - physiology Adult Air Airway Resistance - physiology Asthma - physiopathology Body Temperature Regulation - physiology Bronchi - physiopathology Cold Temperature - adverse effects Female Forced Expiratory Volume - physiology Humans Hyperventilation - physiopathology Male Nasal Cavity - physiology Respiratory Mechanics - physiology |
| title | Integrated response of the upper and lower respiratory tract of asthmatic subjects to frigid air |
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