Genetic Models in Applied Physiology: Selected Contribution: Skeletal muscle capillarity and enzyme activity in rats selectively bred for running endurance

1  University of California San Diego, La Jolla, California 92093; 2  University of Kansas Medical Center, Kansas City, Kansas 66160; and 3  Medical College of Ohio, Toledo, Ohio 43614 To attempt to explain the difference in intrinsic (untrained) endurance running capacity in rats selectively bred o...

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Published in:Journal of applied physiology (1985) 2003-04, Vol.94 (4), p.1682
Main Authors: Howlett, Richard A, Gonzalez, Norberto C, Wagner, Harrieth E, Fu, Zhenxing, Britton, Steven L, Koch, Lauren G, Wagner, Peter D
Format: Article
Language:English
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Summary:1  University of California San Diego, La Jolla, California 92093; 2  University of Kansas Medical Center, Kansas City, Kansas 66160; and 3  Medical College of Ohio, Toledo, Ohio 43614 To attempt to explain the difference in intrinsic (untrained) endurance running capacity in rats selectively bred over seven generations for either low (LCR) or high running capacity (HCR), the relationship among skeletal muscle capillarity, fiber composition, enzyme activity, and O 2 transport was studied. Ten females from each group [body wt: 228 g (HCR), 247 g (LCR); P  = 0.03] were studied at 25 wk of age. Peak normoxic maximum O 2 consumption and muscle O 2 conductance were previously reported to be 12 and 33% higher, respectively, in HCR, despite similar ventilation, arterial O 2 saturation, and a cardiac output that was
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.00556.2002