Renal Cell-to-Cell Communication via Extracellular ATP

Peter Komlosi , Attila Fintha and P. Darwin Bell Departments of Medicine and Physiology, Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama pkomlosi{at}uab.edu In the kidney, macula densa cells communicate with the mesangial cell-afferent arteriolar smooth muscle cell c...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2005-04, Vol.20 (2), p.86-90
Main Authors: Komlosi, Peter, Fintha, Attila, Bell, P. Darwin
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Animals
Cell Communication - physiology
Extracellular Space - metabolism
Humans
Kidney - cytology
Kidney - physiology
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Summary:Peter Komlosi , Attila Fintha and P. Darwin Bell Departments of Medicine and Physiology, Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama pkomlosi{at}uab.edu In the kidney, macula densa cells communicate with the mesangial cell-afferent arteriolar smooth muscle cell complex through ATP signaling. This signaling process involves release of ATP across the macula densa basolateral membrane through a maxi anion channel and the interaction of ATP with purinergic P2 receptors.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00002.2005