The KCNQ1 Potassium Channel: From Gene to Physiological Function

Thomas Jespersen 1 , Morten Grunnet 1 ,2 and Søren-Peter Olesen 1 ,2 1 Department of Medical Physiology and Danish Arrhythmia Research Center, The Panum Institute, University of Copenhagen, Copenhagen, Denmark, and 2 NeuroSearch, Ballerup, Denmark The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium ch...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2005-12, Vol.20 (6), p.408-416
Main Authors: Jespersen, Thomas, Grunnet, Morten, Olesen, Soren-Peter
Format: Article
Language:English
Subjects:
Animals
Electrophysiology
Epithelium - physiology
Heart - physiology
Humans
KCNQ1 Potassium Channel - genetics
KCNQ1 Potassium Channel - physiology
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Summary:Thomas Jespersen 1 , Morten Grunnet 1 ,2 and Søren-Peter Olesen 1 ,2 1 Department of Medical Physiology and Danish Arrhythmia Research Center, The Panum Institute, University of Copenhagen, Copenhagen, Denmark, and 2 NeuroSearch, Ballerup, Denmark The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium channel plays a crucial role in shaping the cardiac action potential as well as in controlling the water and salt homeostasis in several epithelial tissues. KCNQ1 channels in these tissues are tightly regulated by auxiliary proteins and accessory factors, capable of modulating the properties of the channel complexes. This paper reviews the current knowledge about the KCNQ1 channel with a major focus on interacting proteins and physiological functions.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00031.2005