Clinical usefulness of {alpha}-crystallin antibodies in non-small cell lung cancer patients

Department of Biology, Medical University, Sofia, Bulgaria *Corresponding author. Department of Internal Medicine, Georgi Sofiiski 1 str., Sofia, Bulgaria. Tel.: +359889107854. E-mail address : cherneva_radost{at}yahoo.com (R. Cherneva). The non-invasive approach of finding biomarkers in peripheral...

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Published in:Interactive cardiovascular and thoracic surgery 2010-01, Vol.10 (1), p.14
Main Authors: Cherneva, Radostina, Petrov, Danail, Georgiev, Ognian, Trifonova, Nedka
Format: Article
Language:English
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Summary:Department of Biology, Medical University, Sofia, Bulgaria *Corresponding author. Department of Internal Medicine, Georgi Sofiiski 1 str., Sofia, Bulgaria. Tel.: +359889107854. E-mail address : cherneva_radost{at}yahoo.com (R. Cherneva). The non-invasive approach of finding biomarkers in peripheral blood of cancer patients makes it useful for clinical application and cancer screening. The aim of the study was to explore the clinical utility of -crystallin antibodies as markers for diagnosis of non-small cell lung cancer (NSCLC) and screening among high-risk groups. -Crystallin antibodies were detected with enzyme-linked immunosorbent assay (ELISA) in 51 NSCLC patients, 38 high-risk chronic obstructive pulmonary disease (COPD) patients and 52 age and sex matched healthy volunteers. -Crystallin IgG antibodies differed significantly between the groups of cancer patients and the healthy volunteers ( P
ISSN:1569-9293
1569-9285
DOI:10.1510/icvts.2009.213546