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Inducible nitric oxide synthase polymorphism is associated with susceptibility to Henoch-Schönlein purpura in northwestern Spain
OBJECTIVE: To assess the contribution of 2 polymorphisms within the inducible nitric oxide (NOS2A) promoter region to the susceptibility to Henoch-Schönlein purpura (HSP), and to determine if implications exist with severe systemic complications of HSP, in particular with severe renal involvement a...
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Published in: | Journal of rheumatology 2005-06, Vol.32 (6), p.1081 |
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container_issue | 6 |
container_start_page | 1081 |
container_title | Journal of rheumatology |
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creator | Javier Martin Laura Paco Maria P Ruiz Miguel A Lopez-Nevot Carlos Garcia-Porrua Mahsa M Amoli Maria C Calviño William E R Ollier Miguel A Gonzalez-Gay |
description | OBJECTIVE: To assess the contribution of 2 polymorphisms within the inducible nitric oxide (NOS2A) promoter region to the
susceptibility to Henoch-Schönlein purpura (HSP), and to determine if implications exist with severe systemic complications
of HSP, in particular with severe renal involvement and permanent renal dysfunction (renal sequelae). METHODS: Fifty-eight
patients from Northwest Spain with primary cutaneous vasculitis classified as HSP were studied. All patients were required
to have had at least 2 years' followup. Patients and ethnically matched controls (n=251) were genotyped by PCR based techniques
for a multiallelic (CCTTT)n and for the biallelic TAAA repeat in the promoter region of the NOS2A gene. RESULTS: HSP patients
exhibited a significantly increased frequency of the NOS2A short (8-11) CCTTTn alleles (OR 1.64, 95% CI 1.09-2.47, p=0.017)
and genotypes (OR 3.59, 95% CI 1.79-7.20, p=0.0002) compared to controls, particularly when patients with nephritis were compared
with controls. However, when the NOS2A TAAA repeat polymorphism was assessed, no differences were found. CONCLUSION: Significant
differences in the NOS2A promoter polymorphism allele and genotype frequency between HSP patients and controls suggest a potential
role for this gene in the susceptibility to HSP and in the development of nephritis. |
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fullrecord | <record><control><sourceid>highwire</sourceid><recordid>TN_cdi_highwire_smallpub3_www32_6_1081</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>www32_6_1081</sourcerecordid><originalsourceid>FETCH-highwire_smallpub3_www32_6_10813</originalsourceid><addsrcrecordid>eNqNij1OwzAYQC1ERUPhDt_EFinObzMjUJnL0C1yHIM_5NiWP0cmc-_EAeBidOAASE96b3hXLON13-dl15TXLCsq3uS8LU9bdkv0URS8rdv9Ddvypq-Lriszdn6x0yJxNAosxoAS3CdOCmi1UQtS4J1ZZxe8RpoBCQSRkyiimiBh1EALSeUjjmgwrhAdHJR1UudHqX_O31_WKLTgl3BBwCWtC1EnRVEFC0cv0N6xzZswpO7_vGMPz0-vj4dc47tOGNRAszDGL2M1pJSqcmgHXux59e_xF3pOWx8</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Inducible nitric oxide synthase polymorphism is associated with susceptibility to Henoch-Schönlein purpura in northwestern Spain</title><source>Freely Accessible Medical Journals</source><creator>Javier Martin ; Laura Paco ; Maria P Ruiz ; Miguel A Lopez-Nevot ; Carlos Garcia-Porrua ; Mahsa M Amoli ; Maria C Calviño ; William E R Ollier ; Miguel A Gonzalez-Gay</creator><creatorcontrib>Javier Martin ; Laura Paco ; Maria P Ruiz ; Miguel A Lopez-Nevot ; Carlos Garcia-Porrua ; Mahsa M Amoli ; Maria C Calviño ; William E R Ollier ; Miguel A Gonzalez-Gay</creatorcontrib><description>OBJECTIVE: To assess the contribution of 2 polymorphisms within the inducible nitric oxide (NOS2A) promoter region to the
susceptibility to Henoch-Schönlein purpura (HSP), and to determine if implications exist with severe systemic complications
of HSP, in particular with severe renal involvement and permanent renal dysfunction (renal sequelae). METHODS: Fifty-eight
patients from Northwest Spain with primary cutaneous vasculitis classified as HSP were studied. All patients were required
to have had at least 2 years' followup. Patients and ethnically matched controls (n=251) were genotyped by PCR based techniques
for a multiallelic (CCTTT)n and for the biallelic TAAA repeat in the promoter region of the NOS2A gene. RESULTS: HSP patients
exhibited a significantly increased frequency of the NOS2A short (8-11) CCTTTn alleles (OR 1.64, 95% CI 1.09-2.47, p=0.017)
and genotypes (OR 3.59, 95% CI 1.79-7.20, p=0.0002) compared to controls, particularly when patients with nephritis were compared
with controls. However, when the NOS2A TAAA repeat polymorphism was assessed, no differences were found. CONCLUSION: Significant
differences in the NOS2A promoter polymorphism allele and genotype frequency between HSP patients and controls suggest a potential
role for this gene in the susceptibility to HSP and in the development of nephritis.</description><identifier>ISSN: 0315-162X</identifier><identifier>EISSN: 1499-2752</identifier><identifier>PMID: 15940772</identifier><language>eng</language><publisher>The Journal of Rheumatology</publisher><ispartof>Journal of rheumatology, 2005-06, Vol.32 (6), p.1081</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Javier Martin</creatorcontrib><creatorcontrib>Laura Paco</creatorcontrib><creatorcontrib>Maria P Ruiz</creatorcontrib><creatorcontrib>Miguel A Lopez-Nevot</creatorcontrib><creatorcontrib>Carlos Garcia-Porrua</creatorcontrib><creatorcontrib>Mahsa M Amoli</creatorcontrib><creatorcontrib>Maria C Calviño</creatorcontrib><creatorcontrib>William E R Ollier</creatorcontrib><creatorcontrib>Miguel A Gonzalez-Gay</creatorcontrib><title>Inducible nitric oxide synthase polymorphism is associated with susceptibility to Henoch-Schönlein purpura in northwestern Spain</title><title>Journal of rheumatology</title><description>OBJECTIVE: To assess the contribution of 2 polymorphisms within the inducible nitric oxide (NOS2A) promoter region to the
susceptibility to Henoch-Schönlein purpura (HSP), and to determine if implications exist with severe systemic complications
of HSP, in particular with severe renal involvement and permanent renal dysfunction (renal sequelae). METHODS: Fifty-eight
patients from Northwest Spain with primary cutaneous vasculitis classified as HSP were studied. All patients were required
to have had at least 2 years' followup. Patients and ethnically matched controls (n=251) were genotyped by PCR based techniques
for a multiallelic (CCTTT)n and for the biallelic TAAA repeat in the promoter region of the NOS2A gene. RESULTS: HSP patients
exhibited a significantly increased frequency of the NOS2A short (8-11) CCTTTn alleles (OR 1.64, 95% CI 1.09-2.47, p=0.017)
and genotypes (OR 3.59, 95% CI 1.79-7.20, p=0.0002) compared to controls, particularly when patients with nephritis were compared
with controls. However, when the NOS2A TAAA repeat polymorphism was assessed, no differences were found. CONCLUSION: Significant
differences in the NOS2A promoter polymorphism allele and genotype frequency between HSP patients and controls suggest a potential
role for this gene in the susceptibility to HSP and in the development of nephritis.</description><issn>0315-162X</issn><issn>1499-2752</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqNij1OwzAYQC1ERUPhDt_EFinObzMjUJnL0C1yHIM_5NiWP0cmc-_EAeBidOAASE96b3hXLON13-dl15TXLCsq3uS8LU9bdkv0URS8rdv9Ddvypq-Lriszdn6x0yJxNAosxoAS3CdOCmi1UQtS4J1ZZxe8RpoBCQSRkyiimiBh1EALSeUjjmgwrhAdHJR1UudHqX_O31_WKLTgl3BBwCWtC1EnRVEFC0cv0N6xzZswpO7_vGMPz0-vj4dc47tOGNRAszDGL2M1pJSqcmgHXux59e_xF3pOWx8</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Javier Martin</creator><creator>Laura Paco</creator><creator>Maria P Ruiz</creator><creator>Miguel A Lopez-Nevot</creator><creator>Carlos Garcia-Porrua</creator><creator>Mahsa M Amoli</creator><creator>Maria C Calviño</creator><creator>William E R Ollier</creator><creator>Miguel A Gonzalez-Gay</creator><general>The Journal of Rheumatology</general><scope/></search><sort><creationdate>20050601</creationdate><title>Inducible nitric oxide synthase polymorphism is associated with susceptibility to Henoch-Schönlein purpura in northwestern Spain</title><author>Javier Martin ; Laura Paco ; Maria P Ruiz ; Miguel A Lopez-Nevot ; Carlos Garcia-Porrua ; Mahsa M Amoli ; Maria C Calviño ; William E R Ollier ; Miguel A Gonzalez-Gay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-highwire_smallpub3_www32_6_10813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Javier Martin</creatorcontrib><creatorcontrib>Laura Paco</creatorcontrib><creatorcontrib>Maria P Ruiz</creatorcontrib><creatorcontrib>Miguel A Lopez-Nevot</creatorcontrib><creatorcontrib>Carlos Garcia-Porrua</creatorcontrib><creatorcontrib>Mahsa M Amoli</creatorcontrib><creatorcontrib>Maria C Calviño</creatorcontrib><creatorcontrib>William E R Ollier</creatorcontrib><creatorcontrib>Miguel A Gonzalez-Gay</creatorcontrib><jtitle>Journal of rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Javier Martin</au><au>Laura Paco</au><au>Maria P Ruiz</au><au>Miguel A Lopez-Nevot</au><au>Carlos Garcia-Porrua</au><au>Mahsa M Amoli</au><au>Maria C Calviño</au><au>William E R Ollier</au><au>Miguel A Gonzalez-Gay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inducible nitric oxide synthase polymorphism is associated with susceptibility to Henoch-Schönlein purpura in northwestern Spain</atitle><jtitle>Journal of rheumatology</jtitle><date>2005-06-01</date><risdate>2005</risdate><volume>32</volume><issue>6</issue><spage>1081</spage><pages>1081-</pages><issn>0315-162X</issn><eissn>1499-2752</eissn><abstract>OBJECTIVE: To assess the contribution of 2 polymorphisms within the inducible nitric oxide (NOS2A) promoter region to the
susceptibility to Henoch-Schönlein purpura (HSP), and to determine if implications exist with severe systemic complications
of HSP, in particular with severe renal involvement and permanent renal dysfunction (renal sequelae). METHODS: Fifty-eight
patients from Northwest Spain with primary cutaneous vasculitis classified as HSP were studied. All patients were required
to have had at least 2 years' followup. Patients and ethnically matched controls (n=251) were genotyped by PCR based techniques
for a multiallelic (CCTTT)n and for the biallelic TAAA repeat in the promoter region of the NOS2A gene. RESULTS: HSP patients
exhibited a significantly increased frequency of the NOS2A short (8-11) CCTTTn alleles (OR 1.64, 95% CI 1.09-2.47, p=0.017)
and genotypes (OR 3.59, 95% CI 1.79-7.20, p=0.0002) compared to controls, particularly when patients with nephritis were compared
with controls. However, when the NOS2A TAAA repeat polymorphism was assessed, no differences were found. CONCLUSION: Significant
differences in the NOS2A promoter polymorphism allele and genotype frequency between HSP patients and controls suggest a potential
role for this gene in the susceptibility to HSP and in the development of nephritis.</abstract><pub>The Journal of Rheumatology</pub><pmid>15940772</pmid></addata></record> |
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title | Inducible nitric oxide synthase polymorphism is associated with susceptibility to Henoch-Schönlein purpura in northwestern Spain |
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