Synthesis and potential antimicrobial studies on some Mannich bases carrying imidazole moiety

Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl-4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione (3) was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-th...

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Bibliographic Details
Published in:Acta Pharmaceutica 2013, Vol.63 (2), p.231
Main Authors: FRANK, PRIYA VINEETHA, POOJARY, MAHESHA MANJUNATHA, DAMODARA, NARAL, CHIKKANNA, CHANDRASHEKHAR
Format: Web Resource
Language:English
Subjects:
antibacterial activity
antifungal activity
imidazole derivatives
Mannich bases
oxadiazole
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Summary:Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl-4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione (3) was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thiones (4a-j). The structure of the title compounds was elucidated by elemental analysis and spectral data. The newly synthesized Mannich bases were screened for their antibacterial and antifungal activity. Many of these compounds exhibited potent antifungal activity.
ISSN:1330-0075
1846-9558
DOI:10.2478/acph-2013-0016