MiR-196a2 rs11614913 T＞C Polymorphism is Associated with an Increased Risk of Tetralogy of Fallot in a Chinese Population

Background: MicroRNAs (miRNAs) are a family of endogenous, small, noncoding single-stranded RNAs that act as post-transcriptional gene regulatory elements. MiRNA polymorphisms may be associated with susceptibility to congenital heart disease (CHD). The aim of this study was to evaluate the impact of...

Full description

Saved in:
Bibliographic Details
Published in:Acta Cardiologica Sinica 2015-01, Vol.31 (1), p.018-023
Main Authors: Huang, Jian-Bing, Mei, Ju, Jiang, Lian-Yong, Jiang, Zhao-Lei, Liu, Hao, Zhang, Jun-Wen, Ding, Fang-Bao
Format: Article
Language:Chinese
Subjects:
Congenital heart disease
MEDLINE
MiRNA
Molecular epidemiology
Polymorphisms
SCI
Scopus
Tetralogy of Fallot
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: MicroRNAs (miRNAs) are a family of endogenous, small, noncoding single-stranded RNAs that act as post-transcriptional gene regulatory elements. MiRNA polymorphisms may be associated with susceptibility to congenital heart disease (CHD). The aim of this study was to evaluate the impact of miRNA single nucleotide polymorphisms (SNPs) on CHD susceptibility. Methods: We genotyped two functional SNPs, miR-196a2 rs11614913 and miR-146a rs2910164, in a case-control cohort of 173 Chinese patients with tetralogy of Fallot (TOF) and 207 non-CHD controls. Results: When the miR-196a2 rs11614913 TT homozygote genotype was used as the reference group, the TC genotype was not associated with an increased risk of TOF. The CC genotype was associated with a borderline significantly increased risk for TOF. In the recessive model, when themiR-196a2 rs11614913 TT/TC genotypeswere used as the reference group, the CC homozygote genotype was associated with a significantly increased risk of TOF (OR = 1.96, 95% CI = 1.18-
ISSN:1011-6842