High Sensitivity C Reactive Protein (hs-CRP) in Adolescent and Young Adult Patients with History of Kawasaki Disease

Background: For children with a history of Kawasaki disease (KD), low grade inflammation was generally reported to be associated with persistent coronary artery lesions (CAL). However, this association has not been clearly demonstrated to hold true in KD adolescents and young adults (10-25 years of...

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Published in:Acta Cardiologica Sinica 2015-11, Vol.31 (6), p.473-477
Main Authors: Chen,Yung-Chuan, Shen,Ching-Tsuen, Wang,Nan-Koong, Huang,Yi-Ling, Chiu,Hsin-Hui, Chen,Chun-An, Chiu,Shuenn-Nan, Lin,Ming-Tai, Jou-Kou Wang, Mei-Hwan Wu
Format: Article
Language:Chinese
Subjects:
Adolescents
High sensitivity-C reactive protein
Kawasaki disease
MEDLINE
SCI
Scopus
Young adult
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Summary:Background: For children with a history of Kawasaki disease (KD), low grade inflammation was generally reported to be associated with persistent coronary artery lesions (CAL). However, this association has not been clearly demonstrated to hold true in KD adolescents and young adults (10-25 years of age). Methods: We enrolled 104 subjects into our study, who were separated into the following 3 groups and controls: 1): 22 KD patients with angiography-confirmed CAL which persisted for an average of 12.5 years after onset of KD; 2) 38 KD patients with regressed aneurysms; 3) 44 KD patients without any coronary complications from the disease onset; and 4) 31 age-matched (18.7 1.88 years old) healthy controls. Plasma levels of high-sensitivity C reactive protein (hs-CRP) were measured for all participants. Results: Plasma levels of hs-CRP were significantly higher in KD patients than in the controls, regardless of their coronary severity. However, there was no significant difference in hs-CRP levels among KD patien
ISSN:1011-6842