Increased Risk of Venous Thromboembolism in Women with Uterine Leiomyoma: A Nationwide, Population-Based Case-Control Study

Background: Venous thromboembolism (VTE) is a sex-specific disease that has different presentations between men and women. Women with uterine leiomyoma can present with VTE without exhibiting the traditional risk factors. We investigated the relationship between a history of uterine leiomyoma and th...

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Bibliographic Details
Published in:Acta Cardiologica Sinica 2018-01, Vol.34 (1), p.066-076
Main Authors: Hung-Kai Huang, Chew-Teng Kor, Ching-Pei Chen, Hung-Te Chen, Po-Ta Yang, Chen-Dao Tsai, Ching-Hui Huang
Format: Article
Language:Chinese
Subjects:
MEDLINE
SCI
Scopus
Uterine leiomyoma
Venous thromboembolism
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Summary:Background: Venous thromboembolism (VTE) is a sex-specific disease that has different presentations between men and women. Women with uterine leiomyoma can present with VTE without exhibiting the traditional risk factors. We investigated the relationship between a history of uterine leiomyoma and the risk of VTE using the National Health Insurance Research Database (NHIRD). Methods: We conducted a retrospective, nationwide, population-based case-control study using the NHIRD. We identified 2,282 patients with diagnosed VTE and 392,635 subjects without VTE from 2000 to 2013. After development of an age and index diagnosis year frequency-matchedmodel and propensity score-matched model, 2models with a case-to-control ratio of 1 to 4 were established. Using the diagnosis of uterine leiomyoma as the exposure factor, conditional logistic regression was performed to examine the association between uterine leiomyoma and VTE. Multiple logistic regression analysis was used to investigate the joint effect of uterine lei
ISSN:1011-6842