The Relationship between Nesfatin-1 Levels and SYNTAX Score in Patients with Non-ST Segment Elevation Myocardial Infarction

Objective: Nesfatin-1 is a novel anorectic neuropeptide with potent metabolic regulatory effects. It regulates blood pressure, heart rate, cardiomyocyte metabolism and permeability. SYNTAX score, which is an angiographic scoring system, defines the grade and complexity of coronary artery disease (CA...

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Bibliographic Details
Published in:Acta Cardiologica Sinica 2018-09, Vol.34 (5), p.386-393
Main Authors: Mevlüt Serdar Kuyumcu, Aliye Kuyumcu, Ça r Yayla, Mustafa Bilal Özbay, Sefa Ünal, Burak Açar, Cemil Nural, Almila enat, Gülhan Samur
Format: Article
Language:Chinese
Subjects:
Coronary artery disease
MEDLINE
Nesfatin-1
SCI
Scopus
SYNTAX score
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Summary:Objective: Nesfatin-1 is a novel anorectic neuropeptide with potent metabolic regulatory effects. It regulates blood pressure, heart rate, cardiomyocyte metabolism and permeability. SYNTAX score, which is an angiographic scoring system, defines the grade and complexity of coronary artery disease (CAD).We aimed to evaluate the relationship between nesfatin-1 level and severity of CAD according to the SYNTAX score in patients with non-ST segment elevation myocardial infarction (NSTEMI). Methods: A total of 109 subjects were enrolled into the study, of whom 80 underwent coronary angiography (CA) with the diagnosis of NSTEMI and 29 had normal coronary arteries detected in CA. NSTEMI patients were divided into 2 groups: low SYNTAX score (＜ 32) (45 patients) and high SYNTAX score ( 32) (35 patients). Results: The NSTEMI patients with a high SYNTAX score (score 32) had a lower serum nesfatin-1 level (62 pg/ml; 39-98) compared to the NSTEMI patients with a low SYNTAX score (score ＜ 32) (138 pg/ml; 65-286) and the con
ISSN:1011-6842