Prescription Pattern in Angiotensin Receptor Neprilysin Inhibitor is Associated with Heart Failure Events

Background: Angiotensin receptor neprilysin inhibition (ARNI) is superior to enalapril in reducing the risk of cardiovascular death and heart failure hospitalization (HFH). However, whether prescription pattern is associated with heart failure outcome is unknown. Method: This is a retrospective stud...

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Published in:Acta Cardiologica Sinica 2023-01, Vol.39 (1), p.144-150
Main Authors: Wei-Tsung Wu, Shih-Han Wang, Ya-Lin Wang, Tsung-Hsien Lin, Wen-Ter Lai, Sheng-Hsiung Sheu
Format: Article
Language:Chinese
Subjects:
Angiotensin receptor neprilysin inhibitor
Cardiac pharmacology
Heart failure
MEDLINE
Prescribing habit
SCIE
Scopus
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Summary:Background: Angiotensin receptor neprilysin inhibition (ARNI) is superior to enalapril in reducing the risk of cardiovascular death and heart failure hospitalization (HFH). However, whether prescription pattern is associated with heart failure outcome is unknown. Method: This is a retrospective study of 153 patients who received ARNI in a tertiary medical center in Taiwan. We analyzed the impact of dose up-titration and prescription timing including during initial admission, within 3 months after initial HFH discharge, and at outpatient clinics without prior HFH. The primary endpoint was the composite of cardiovascular death and HFH. Results: After a mean follow-up period of 287 ± 197 days, the primary endpoint occurred in 43 (28.1%) subjects. Patients without and with a primary endpoint significantly differed in terms of history of valvular heart disease (VHD, p = 0.006), ventricular tachyarrhythmia (VT, p = 0.043), percutaneous coronary intervention (p = 0.007), coronary artery bypass grafting (p = 0.002),
ISSN:1011-6842