Isolated V-lesion in an ABO-incompatible kidney transplant recipient receiving rituximab

We report an ABO-incompatible kidney transplant performed on a 69-year-old female patient, whose donor was her 69-year-old husband. The patient received an immunosuppressive protocol using rituximab without splenectomy. Renal biopsy was done on posttransplant day 8 due to poor early graft function,...

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Bibliographic Details
Published in:Experimental and clinical transplantation 2019-10, Vol.17 (5), p.678-680
Main Authors: Iwai,Tomoaki, Uchida,Junji, Kabei,Kazuya, Nishide,Shunji, Kuwabara,Nobuyuki, Naganuma,Toshihide, Kumada,Norihiko, Takemoto,Yoshiaki, Nakatani,Tatsuya
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Language:English
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Summary:We report an ABO-incompatible kidney transplant performed on a 69-year-old female patient, whose donor was her 69-year-old husband. The patient received an immunosuppressive protocol using rituximab without splenectomy. Renal biopsy was done on posttransplant day 8 due to poor early graft function, and an isolated v-lesion was found, which responded to steroid pulse therapy and gusperimus hydrochloride administration. Our results indicate that isolated v-lesions can occur in ABO-incompatible kidney transplant recipients receiving rituximab and that this finding should be treated as acute rejection. To our knowledge, this is the first report of an isolated v-lesion in an ABO-incompatible kidney transplant recipient who had been administered rituximab.
ISSN:1304-0855
2146-8427
DOI:10.6002/ect.2017.0062